A geranyl resorcylate with diverse biological activities
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Hericene A

Item No. 45578

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
hexadecanoic acid, [4-[(2E)-3,7-dimethyl-2,6-octadien-1-yl]-2 formyl-3-hydroxy-5-methoxyphenyl]methyl ester
CAS Number
157207-54-0
Synonyms
  • 5′-Deoxohericenone C
Molecular Formula
C35H56O5
Formula Weight
556.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble: 0.1-1 mg/ml
SMILES
CCCCCCCCCCCCCCCC(OCC1=CC(OC)=C(C(O)=C1C=O)C/C=C(C)/CC/C=C(C)\C)=O
InChi Code
InChI=1S/C35H56O5/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-22-34(37)40-27-30-25-33(39-5)31(35(38)32(30)26-36)24-23-29(4)21-19-20-28(2)3/h20,23,25-26,38H,6-19,21-22,24,27H2,1-5H3/b29-23+
InChi Key
PLUINHYLFTYIKB-BYNJWEBRSA-N
Origin
Fungus/Hericium erinaceus
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Hericene A is a polyketide synthase-derived geranyl resorcylate that has been found in H. erinaceus and has diverse biological activities.1,2,3,4,5 It is an inhibitor of α-glucosidase (IC50 = 6.7 µM).3 Hericene A (1-100 µM) decreases LPS-induced TNF-α, IL-6, and nitric oxide (NO) production in RAW 264.7 cells.4 It increases the axon length of primary rat hippocampal neurons and improves recognition memory in mice.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, J., Zeng, X., Yang, Y.L., et al. Genomic and transcriptomic analyses reveal differential regulation of diverse terpenoid and polyketides secondary metabolites in Hericium erinaceus. Sci. Rep. 7(1), 10151 (2017).

    2. Kobayashi, S., Hamada, Y., Yasumoto, T., et al. Total syntheses and endoplasmic reticulum stress suppressive activities of hericenes A−C and their derivatives. Tetrahedron Lett. 59(18), 1733-1736 (2018).

    3. Lee, S.K., Ryu, S.H., Turk, A., et al. Characterization of α-glucosidase inhibitory constituents of the fruiting body of lion’s mane mushroom (Hericium erinaceus). J. Ethnaopharmacol. 262, 113197 (2020).

    4. Xie, G., Tang, L., Xie, Y., et al. Secondary metabolites from Hericium erinaceus and their anti-inflammatory activities. Molecules 27(7), 2157 (2022).

    5. Martínez-Mármol, R., Chai, Y., Conroy, J.N., et al. Hericerin derivatives activates a pan-neurotrophic pathway in central hippocampal neurons converging to ERK1/2 signaling enhancing spatial memory. J. Neurochem. 165(6), 791-808 (2023).