A peptide linker molecule
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Mal-Ala-Ala-PAB-PNP

Item No. 45587

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-alanyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]-phenyl]-L-alaninamide
CAS Number
2003260-14-6
Molecular Formula
C30H33N5O10
Formula Weight
623.6
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(OCC1=CC=C(NC([C@@H](NC([C@@H](NC(CCCCCN2C(C=CC2=O)=O)=O)C)=O)C)=O)C=C1)OC3=CC=C([N+]([O-])=O)C=C3
InChi Code
InChI=1S/C30H33N5O10/c1-19(31-25(36)6-4-3-5-17-34-26(37)15-16-27(34)38)28(39)32-20(2)29(40)33-22-9-7-21(8-10-22)18-44-30(41)45-24-13-11-23(12-14-24)35(42)43/h7-16,19-20H,3-6,17-18H2,1-2H3,(H,31,36)(H,32,39)(H,33,40)/t19-,20-/m0/s1
InChi Key
GEMSBDIHVHIIDT-PMACEKPBSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    5 mg

    $59

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    10 mg

    $106

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    25 mg

    $236

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    50 mg

    $384

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    Product Description

    Mal-Ala-Ala-PAB-PNP is a peptide linker molecule. It contains a maleimidocaproyl (Mal) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to active compounds.1 It can be used in the synthesis of antibody-drug conjugates (ADCs).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheng-Sánchez, I., Moya-Utrera, F., Porras-Alcalá, C., et al. Antibody-drug conjugates containing payloads from marine origin. Mar. Drugs 20(8), 494 (2022).