An inhibitor of eIF4A3
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

eIF4A3-IN-1

Item No. 45609

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-[4-[[(3S)-4-(4-bromobenzoyl)-3-(4-chlorophenyl)-1-piperazinyl]carbonyl]-5-methyl-1H-pyrazol-1-yl]-benzonitrile
CAS Number
2095486-67-0
Synonyms
  • eIF4A-III-IN-1
  • eIF4A3 Inhibitor 1
  • Eukaryotic Initiation Factor 4A3 Inhibitor 1
  • Eukaryotic Initiation Factor 4A-III Inhibitor 1
  • T-202
Molecular Formula
C29H23BrClN5O2
Formula Weight
588.9
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=CC=C(C=C1)Br)N2[C@@H](C3=CC=C(C=C3)Cl)CN(CC2)C(C4=C(N(C5=CC(C#N)=CC=C5)N=C4)C)=O
InChi Code
InChI=1S/C29H23BrClN5O2/c1-19-26(17-33-36(19)25-4-2-3-20(15-25)16-32)29(38)34-13-14-35(28(37)22-5-9-23(30)10-6-22)27(18-34)21-7-11-24(31)12-8-21/h2-12,15,17,27H,13-14,18H2,1H3/t27-/m1/s1
InChi Key
BDGKKHWJYBQRIE-HHHXNRCGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $155

    Add

    5 mg

    $426

    Add

    10 mg

    $698

    Add

    25 mg

    $1,356

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    eIF4A3-IN-1 is an inhibitor of eukaryotic initiation factor 4A-III (eIF4A3).1 It selectively inhibits the ATPase activity of eIF4A3 (IC50 = 0.26 µM) over the ATPase activities of eIF4A1, eIF4A2, DExH-box protein DHX29, and RNA helicase Brr2 (IC50s = >100 µM for all). eIF4A3-IN-1 inhibits nonsense-mediated RNA decay (NMD) in HEK293 cells at 10 µM and reduces proliferation, colony formation, and tumorsphere size in HepG2, Hep3B, and SNU-387 hepatocellular carcinoma cells at 3 nM.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ito, M., Tanaka, T., Cary, D.R., et al. Discovery of novel 1,4-diacylpiperazines as selective and cell-active eIF4A3 inhibitors. J. Med. Chem. 60(8), 3335-3351 (2017).

    2. López-Cánovas, J.L., Hermán-Sánchez, N., Moreno-Montilla, M.T., et al. Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing. Clin. Transl. Med. 12(11), e1102 (2022).