A positive allosteric modulator of mGluR3
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mGluR3 Modulator-1

Item No. 45616

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-ethyl-5,6,7,8-tetrahydro-3-(4-morpholinyl)-4-isoquinolinecarbonitrile
CAS Number
374548-18-2
Molecular Formula
C16H21N3O
Formula Weight
271.4
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
CCC1=NC(N2CCOCC2)=C(C#N)C3=C1CCCC3
InChi Code
InChI=1S/C16H21N3O/c1-2-15-13-6-4-3-5-12(13)14(11-17)16(18-15)19-7-9-20-10-8-19/h2-10H2,1H3
InChi Key
IPMSLSGLVYALQK-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $99

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    10 mg

    $178

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    25 mg

    $322

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    50 mg

    $594

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    Product Description

    mGluR3 modulator-1 is a positive allosteric modulator (PAM) of metabotropic glutamate receptor 3 (mGluR3).1 It enhances glutamate-induced calcium mobilization in HEK293T cells expressing mGluR3 and Gqi5 (EC50 = 1-10 µM).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Potnick, J. Positive allosteric modulators of MGLUR3. (2014).