An internal standard for the quantification of D-pantothenic acid
Related Products
Unlabeled Version(s)
17288D-Pantothenic Acid (sodium salt)
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D-Pantothenic Acid-d4 (calcium salt)

Item No. 45632

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(R)-3-(2,4-dihydroxy-3,3-dimethylbutanamido)propanoate-2,2,3,3-d4, hemicalicum salt
Synonyms
  • Vitamin B5-d4
Molecular Formula
C9H12D4NO5 • 1/2Ca
Formula Weight
484.6
Purity
≥99% deuterated forms (d1-d4)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: SolubleDMSO: SolubleWater: Soluble
SMILES
OCC(C)(C)[C@@H](O)C(NC([2H])([2H])C([2H])([2H])C([O-])=O)=O.OCC(C)(C)[C@@H](O)C(NC([2H])([2H])C([2H])([2H])C([O-])=O)=O.[Ca+2]
InChi Code
InChI=1S/2C9H17NO5.Ca/c2*1-9(2,5-11)7(14)8(15)10-4-3-6(12)13;/h2*7,11,14H,3-5H2,1-2H3,(H,10,15)(H,12,13);/q;;+2/p-2/t2*7-;/m00./s1/i2*3D2,4D2;
InChi Key
FAPWYRCQGJNNSJ-QOAYZYBASA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    1 mg

    $599

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    Product Description

    D-Pantothenic acid-d4 is intended for use as an internal standard for the quantification of D-pantothenic acid (Item No. 17288) by GC- or LC-MS. D-Pantothenic acid is the biologically active enantiomer of vitamin B5 and a biosynthetic precursor of coenzyme A (CoA).1 A D-pantothenic acid-deficient diet reduces food intake, body weight gain, and liver, heart, spleen, testes, and gastrocnemius muscle weight in weaning rats. Fecal levels of D-pantothenic acid are increased in patients with colorectal cancer.2 Levels of D-pantothenic acid are decreased in postmortem brain tissue from patients with Alzheimer’s disease.3 Formulations containing D-pantothenic acid have been used as dietary supplements.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shibata, K., Kaneko, M., and Fukuwatari, T. D-pantethine has vitamin activity equivalent to D-pantothenic acids for recovering from a deficiency of D-pantothenic acid in rats. J. Nutr. Sci. Vitaminol. (Tokyo) 59(2), 93-99 (2013).

    2. Weir, T.L., Manter, D.K., Sheflin, A.M., et al. Stool microbiome and metabolome differences between colorectal cancer patients and healthy adults. PLoS One 8(8), 70803 (2013).

    3. Xu, J., Patassini, S., Begley, P., et al. Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer’s disease. Biochem. Biophys. Res. Commun. 527(3), 676-681 (2020).