An 8-hydroxyquinoline derivative
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Benzoxiquine

Item No. 45705

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
8-benzoate 8-quinolinol
CAS Number
86-75-9
Synonyms
  • Benzoxyline
  • 8-Benzoyloxyquinoline
  • 8-Hydroxyquinoline Benzoate
  • Oxyquinoline Benzoate
  • 8-Quinolinol Benzoate
  • NSC 3951
Molecular Formula
C16H11NO2
Formula Weight
249.3
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C(C1=CC=CC=C1)OC2=CC=CC3=C2N=CC=C3
InChi Code
InChI=1S/C16H11NO2/c18-16(13-6-2-1-3-7-13)19-14-10-4-8-12-9-5-11-17-15(12)14/h1-11H
InChi Key
BHKPHCKISVSDGV-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $275

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    5 mg

    $756

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    Product Description

    Benzoxiquine is a benzoic acid ester of 8-hydroxyquinoline.1 It inhibits the protein-protein interaction between the synaptic adhesion molecules neurexin-1-α and leucine-rich repeat transmembrane neuronal protein 2 (LRRTM2; IC50 = 45 µM).2 Benzoxiquine inhibits the proliferation of MIA PaCa-2 and PANC-1 pancreatic, HCT116 colon, and KYSE-70 esophageal cancer cells (IC50s = 5.4, 4.9, 3.7, and 6.6 µM, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Anderson, F.A. Final report on the safety assessment of benzoxiquine. J. Toxicol. 16(suppl. 1), 117-122 (1997).

    2. Karki, S., Maksimainen, M.M., Lehtiö, L., et al. Inhibitor screening assay for neurexin-LRRTM adhesion protein interaction involved in synaptic maintenance and neurological disorders. Anal. Biochem. 587, 113463 (2019).

    3. Hu, S., Jin, Y., Liu, Y., et al. Synthesis and mechanistic studies of quinolin-chlorobenzothioate derivatives with proteasome inhibitory activity in pancreatic cancer cell lines. Eur. J. Med. Chem. 158, 884-895 (2018).