A DNA topoisomerase I poison
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Coralyne (chloride)

Item No. 45715

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,3,10,11-tetramethoxy-8-methyl-dibenzo[a,g]quinolizinium, monochloride
CAS Number
38989-38-7
Molecular Formula
C22H22NO4 • Cl
Formula Weight
399.9
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
COC1=CC(C=C2[N+](C=CC3=CC(OC)=C(OC)C=C23)=C4C)=C4C=C1OC.[Cl-]
InChi Code
InChI=1S/C22H22NO4.ClH/c1-13-16-11-21(26-4)20(25-3)10-15(16)8-18-17-12-22(27-5)19(24-2)9-14(17)6-7-23(13)18;/h6-12H,1-5H3;1H/q+1;/p-1
InChi Key
PDYBUYVOPAJLKP-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $87

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    10 mg

    $157

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    25 mg

    $348

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    Cayman Chemical
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    Product Description

    Coralyne is a DNA topoisomerase I poison.1 It inhibits DNA topoisomerase I via stabilization of the DNA-enzyme complex and inhibition of DNA relaxation. It is selective for DNA topoisomerase I over DNA topoisomerase II at 100 µg/ml.2 Coralyne (100-400 mg/kg) increases survival in P388 and L1210 murine leukemia models.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, L.-K., Rogers, B.D., and Hecht, S.M. Inhibition of topoisomerase I function by coralyne and 5,6-dihydrocoralyne. Chem. Res. Toxicol. 9(1), 75-83 (1996).

    2. Gatto, B., Sanders, M.M., Yu, C., et al. Identification of topoisomerase I as the cytotoxic target of the protoberberine alkaloid coralyne. Cancer Res. 56(12), 2795-2800 (1996).

    3. Zee-Cheng, K.-Y., Paull, K.D., and Cheng, C.C. Experimental antileukemic agents. Coralyne, analogs, and related compounds. J. Med. Chem. 17(3), 347-351 (1974).