An ER ligand
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Androgen Receptor Ligand 3

Item No. 45732

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(17E)-O-(carboxymethyl)oxime, 3-hydroxy-estra-1,3,5(10)-trien-17-one
CAS Number
693227-00-8
Molecular Formula
C20H25NO4
Formula Weight
343.4
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
C[C@@]12[C@](CC/C2=N\OCC(O)=O)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC=C(O)C=C4CC3
InChi Code
InChI=1S/C20H25NO4/c1-20-9-8-15-14-5-3-13(22)10-12(14)2-4-16(15)17(20)6-7-18(20)21-25-11-19(23)24/h3,5,10,15-17,22H,2,4,6-9,11H2,1H3,(H,23,24)/b21-18+/t15-,16-,17+,20+/m1/s1
InChi Key
UZKYYNQEKCAXLJ-YBFXVWRFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $25

    Add

    100 mg

    $48

    Add

    250 mg

    $94

    Add

    500 mg

    $125

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Androgen receptor ligand 3 is an estrogen receptor (ER) ligand (KD = 0.39 µM in a radioligand binding assay) and an oxime derivative of estrone (Item No. 10006485).1 Androgen receptor ligand 3 has been used in the synthesis of a specific and nongenetic IAP-dependent protein eraser (SNIPER) that decreases ERα levels in HT-1080 fibrosarcoma cells.2 Biotin conjugates of androgen receptor ligand 3 have been used in yeast three-hybrid systems.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ratajczak, T., Sheppard, P.N., Capon, R.J., et al. The synthesis and study of some potential affinity labeling reagents for estrogen receptors. Steroids 38(5), 537-555 (1981).

    2. Itoh, Y., Kitaguchi, R., Ishikawa, M., et al. Design, synthesis and biological evaluation of nuclear receptor-degradation inducers. Bioorg. Med. Chem. 19(22), 6768-6778 (2011).

    3. Muddana, S.S., and Peterson, B.R. Facile synthesis of CIDS: biotinylated estrone oximes efficiently heterodimerize estrogen receptor and streptavidin proteins in yeast three hybrid systems. Org. Lett. 6(9), 1409-1412 (2004).