An iron chelator and N-Myc inhibitor
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M606

Item No. 45735

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-(methoxymethyl)-7-[(4-methyl-1-piperidinyl)methyl]-8-quinolinol
CAS Number
298230-09-8
Molecular Formula
C18H24N2O2
Formula Weight
300.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
OC1=C2N=CC=CC2=C(COC)C=C1CN3CCC(CC3)C
InChi Code
InChI=1S/C18H24N2O2/c1-13-5-8-20(9-6-13)11-14-10-15(12-22-2)16-4-3-7-19-17(16)18(14)21/h3-4,7,10,13,21H,5-6,8-9,11-12H2,1-2H3
InChi Key
QPMKGHCNJSRHSS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $25

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    5 mg

    $88

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    10 mg

    $163

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    25 mg

    $313

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    Cayman Chemical
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    Product Description

    M606 is an iron chelator and N-Myc inhibitor.1 It binds iron at a 3:1 ratio. M606 inhibits MYCN transactivation in a reporter assay using SHR6-17 neuroblastoma cells in a concentration-dependent manner. It induces cytotoxicity, decreases N-Myc levels, and increases HIF-1α levels in BE(2)-C and LA-N-1 neuroblastoma cells, effects that can be reversed by ferric iron. M606 (25 mg/kg) increases survival in the TH-MYCN transgenic mouse model of neuroblastoma. It also inhibits P. aeruginosa biofilm formation (EC50 = 19.21 µM).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Pandher, R., Xue, C., Gamble, L.D., et al. The cell-permeable iron chelator M606 inhibits MYCN-driven neuroblastoma via an E2F3-mediated response. Proc. Nat. Acad. Sci. USA 122(23), e2420011122 (2025).

    2. Junker, L.M., and Clardy, J. High-throughput screens for small-molecule inhibitors of Pseudomonas aeruginosa biofilm development. Antimicrob. Agents Chemother. 51(10), 3582-3590 (2007).