A PROTAC that drives TRIM24 degradation
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dTRIM24

Item No. 45749

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S,4R)-1-((S)-15-(tert-butyl)-1-(3-(N-(1,3-dimethyl-2-oxo-6-(3-propoxyphenoxy)-2,3-dihydro-1H-benzo[d]imidazol-5-yl)sulfamoyl)phenyl)-1,13-dioxo-5,8,11-trioxa-2,14-diazahexadecan-16-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
CAS Number
2170695-14-2
Molecular Formula
C55H68N8O13S2
Formula Weight
1113.3
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=S(NC(C=C1C(N(C(N1C)=O)C)=C2)=C2OC3=CC(OCCC)=CC=C3)(C4=CC(C(NCCOCCOCCOCC(N[C@@H](C(C)(C)C)C(N5C[C@@H](C[C@H]5C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)O)=O)=O)=O)=CC=C4)=O
InChi Code
InChI=1S/C55H68N8O13S2/c1-8-20-75-40-12-10-13-41(28-40)76-47-30-45-44(61(6)54(69)62(45)7)29-43(47)60-78(70,71)42-14-9-11-38(26-42)51(66)56-19-21-72-22-23-73-24-25-74-33-48(65)59-50(55(3,4)5)53(68)63-32-39(64)27-46(63)52(67)57-31-36-15-17-37(18-16-36)49-35(2)58-34-77-49/h9-18,26,28-30,34,39,46,50,60,64H,8,19-25,27,31-33H2,1-7H3,(H,56,66)(H,57,67)(H,59,65)/t39-,46+,50-/m1/s1
InChi Key
QUQTXFIMYFMULC-OGOZKGDESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $332

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    10 mg

    $540

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    25 mg

    $1,038

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    Cayman Chemical
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    Product Description

    dTRIM24 is a proteolysis-targeting chimera (PROTAC) containing the ubiquitin ligase TRIM24 ligand IACS-7e conjugated to the von Hippel-Lindau (VHL) ligand VL-269 via a PEG linker.1 It induces degradation of TRIM24 in HEK293-FT cells at 0.25-5 µM with maximum degradation at 5 µM. dTRIM24 (5 µM) reduces growth and induces apoptosis in MOLM-13 leukemia cells.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gechijian, L.N., Buckley, D.L., Lawlor, M.A., et al. Functional TRIM24 degrader via conjugation of ineffectual bromodomain and VHL ligands. Nat. Chem. Biol. 14(4), 405-412 (2018).