A PROTAC that drives androgen receptor degradation
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AZD 9750

Item No. 45751

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-chloro-7-[(3S)-3-[4-[4-[[4-[1-methyl-6-(tetrahydro-2,4-dioxo-1(2H)-pyrimidinyl)-1H-indol-2-yl]-1-piperidinyl]methyl]-1-piperidinyl]phenyl]-1-piperidinyl]-1H-indazole-3-carbonitrile
CAS Number
3056515-10-4
Molecular Formula
C43H48ClN9O2
Formula Weight
758.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
CN1C(C(CC2)CCN2CC(CC3)CCN3C(C=C4)=CC=C4[C@@H]5CCCN(C6=C7NN=C(C#N)C7=C(C=C6)Cl)C5)=CC8=CC=C(N9C(NC(CC9)=O)=O)C=C18
InChi Code
InChI=1S/C43H48ClN9O2/c1-49-38(23-31-6-9-34(24-39(31)49)53-22-16-40(54)46-43(53)55)30-14-18-50(19-15-30)26-28-12-20-51(21-13-28)33-7-4-29(5-8-33)32-3-2-17-52(27-32)37-11-10-35(44)41-36(25-45)47-48-42(37)41/h4-11,23-24,28,30,32H,2-3,12-22,26-27H2,1H3,(H,47,48)(H,46,54,55)/t32-/m1/s1
InChi Key
GOWJHJUMPVCHAN-JGCGQSQUSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $481

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    $1,684

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    Product Description

    AZD 9750 is a proteolysis-targeting chimera (PROTAC) composed of an androgen receptor ligand and a lenalidomide derivative.1 It induces the degradation of wild-type androgen receptor (AR) and drug-resistant mutant AR containing a leucine-to-histidine substitution at position 702 (ARL702H) with half-maximal degradation concentration (DC50) values of 10 and 12 nM, respectively. AZD 9750 (30 mg/kg) decreases tumor volume in a wild-type AR-expressing patient-derived xenograft (PDX) mouse model of prostate cancer.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Scott, J.S., Evans, L., Astles, P.C., et al. Discovery of AZD9750, an orally bioavailable androgen receptor degrader for the treatment of prostate cancer. J. Med. Chem. 69(3), 3209-3232 (2026).