A tubulin destabilizer
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RGN6024

Item No. 45752

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-methoxy-N-[5-[[2-(4-morpholinyl)-5-pyrimidinyl]oxy]-2-thiazolyl]-bicyclo[1.1.1]pentane-1-carboxamide
CAS Number
3055038-20-2
Molecular Formula
C18H21N5O4S
Formula Weight
403.5
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: >20 mg/ml
SMILES
O=C(C12CC(C1)(C2)OC)NC3=NC=C(S3)OC(C=N4)=CN=C4N5CCOCC5
InChi Code
InChI=1S/C18H21N5O4S/c1-25-18-9-17(10-18,11-18)14(24)22-16-21-8-13(28-16)27-12-6-19-15(20-7-12)23-2-4-26-5-3-23/h6-8H,2-5,9-11H2,1H3,(H,21,22,24)
InChi Key
OZQOKIPXKCUQMJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $49

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    5 mg

    $233

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    Cayman Chemical
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    Product Description

    RGN6024 is a tubulin destabilizer.1 It reduces tumor growth in a temozolomide-resistant LN-18 glioblastoma mouse xenograft model when administered orally at doses of 7.5 or 15 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patrón, L.A., Yeoman, H., Ramos, J., et al. RGN6024 is a brain-penetrant, small-molecule tubulin destabilizer for the treatment of glioblastoma. Mol. Cancer Ther. 24(8), 1129-1144 (2025).