A synthetic innate defense regulator peptide
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RP-182 (trifluoroacetate salt)

Item No. 45764

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-lysyl-L-phenylalanyl-L-arginyl-L-lysyl-L-alanyl-L-phenylalanyl-L-lysyl-L-arginyl-L-phenylalanyl-L-phenylalanine, trifluoroacetate salt
Synonyms
  • Lys-Phe-Arg-Lys-Ala-Phe-Lys-Arg-Phe-Phe-OH
Molecular Formula
C69H103N19O11 • XCF3COOH
Formula Weight
1374.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
KFRKAFKRFF-OH
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
NCCCC[C@H](N)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)=O)=O)=O)=O)=O)=O)=O.FC(F)(C(O)=O)F
InChi Code
InChI=1S/C69H103N19O11.C2HF3O2/c1-44(80-60(91)50(31-15-18-36-71)81-62(93)52(33-20-38-78-68(74)75)84-65(96)55(41-46-24-8-3-9-25-46)86-59(90)49(73)30-14-17-35-70)58(89)85-54(40-45-22-6-2-7-23-45)64(95)83-51(32-16-19-37-72)61(92)82-53(34-21-39-79-69(76)77)63(94)87-56(42-47-26-10-4-11-27-47)66(97)88-57(67(98)99)43-48-28-12-5-13-29-48;3-2(4,5)1(6)7/h2-13,22-29,44,49-57H,14-21,30-43,70-73H2,1H3,(H,80,91)(H,81,93)(H,82,92)(H,83,95)(H,84,96)(H,85,89)(H,86,90)(H,87,94)(H,88,97)(H,98,99)(H4,74,75,78)(H4,76,77,79);(H,6,7)/t44-,49-,50-,51-,52-,53-,54-,55-,56-,57-;/m0./s1
InChi Key
USIXGOXRVLSKCK-WACKLBOQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    10 mg

    $145

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    25 mg

    $290

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    Product Description

    RP-182 is a synthetic innate defense regulator (IDR) peptide.1 It binds to CD206 (Kd = 8.37 µM for the human receptor) and induces its closed conformation with an EC50 value of ~11 µM. RP-182 selectively induces phagocytosis, autophagy, and apoptosis in M2 over M1 macrophages. It increases survival and decreases the percentage of stromal CD206+ cells in the tumor microenvironment in a KP16 mouse model of pancreatic cancer. RP-182 decreases renal macrophage and neutrophil infiltration in a mouse model of unilateral ureteral obstruction-induced renal fibrosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Jaynes, J.M., Sable, R.R., M., Bautista, W., et al. Mannose receptor (CD206) activation in tumor-associated macrophages enhances adaptive and innate antitumor immune responses. Sci. Transl. Med. 12(530), eaax6337 (2020).

    2. Cao, H., Chen, X., Jin, R., et al. RP-182 alleviated obstruction-induced renal fibrosis by reprogramming CD206+ macrophages. Front. Pharmacol. 17, 1739457 (2026).