A bioactive peptide
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Immunology & Inflammation

Tetrapeptide PKEK (acetate)

Item No. 45774

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-prolyl-L-lysyl-L-glutamyl-L-lysine, monoacetate
CAS Number
2763584-89-8
Synonyms
  • Pro-Lys-Glu-Lys-OH
  • Tetrapeptide-30
Molecular Formula
C22H40N6O7• C2H4O2
Formula Weight
620.7
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
PKEK-OH
Solubility(Learn about Variance in Solubility)
PBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C([C@@H]1CCCN1)N[C@H](C(N[C@H](C(N[C@H](C(O)=O)CCCCN)=O)CCC(O)=O)=O)CCCCN.OC(C)=O
InChi Code
InChI=1S/C22H40N6O7.C2H4O2/c23-11-3-1-6-15(26-19(31)14-8-5-13-25-14)20(32)27-16(9-10-18(29)30)21(33)28-17(22(34)35)7-2-4-12-24;1-2(3)4/h14-17,25H,1-13,23-24H2,(H,26,31)(H,27,32)(H,28,33)(H,29,30)(H,34,35);1H3,(H,3,4)/t14-,15-,16-,17-;/m0./s1
InChi Key
JQJKOEZUZYXNSZ-SITLLQIKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

    $46

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    25 mg

    $92

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    50 mg

    $150

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    100 mg

    $276

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    Product Description

    Tetrapeptide PKEK is a bioactive peptide.1 It reduces UVB-induced expression of proopiomelanocortin (POMC), IL-6, and TNF-α in primary human epidermal keratinocytes at 1 and 10 µg/ml and IL-8 at 10 µg/ml.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Marini, A., Farwick, M., Grether-Beck, S., et al. Modulation of skin pigmentation by the tetrapeptide PKEK: In vitro and in vivo evidence for skin whitening effects. Exp. Dermatol. 21(2), 140-146 (2012).