A collagen IV-based peptide
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Product Categories

Product Type

Biochemicals
Peptides

Research Area

Cell Biology
ECM & Adhesion Molecules

Tetrapeptide GEKG (trifluoroacetate salt)

Item No. 45775

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
glycyl-L-α-glutamyl-L-lysyl-glycine, trifluoroacetate salt
Synonyms
  • L-Gly-L-Glu-L-Lys-L-Gly
  • Tetrapeptide 21
Molecular Formula
C15H27N5O7 • XCF3COOH
Formula Weight
389.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
GEKG-OH
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(CN)N[C@H](C(N[C@H](C(NCC(O)=O)=O)CCCCN)=O)CCC(O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C15H27N5O7.C2HF3O2/c16-6-2-1-3-9(14(26)18-8-13(24)25)20-15(27)10(4-5-12(22)23)19-11(21)7-17;3-2(4,5)1(6)7/h9-10H,1-8,16-17H2,(H,18,26)(H,19,21)(H,20,27)(H,22,23)(H,24,25);(H,6,7)/t9-,10-;/m0./s1
InChi Key
YLYKLDPEQOQQMT-IYPAPVHQSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $49

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    10 mg

    $78

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    25 mg

    $184

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    50 mg

    $294

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    Product Description

    Tetrapeptide GEKG is a peptide corresponding to amino acids 167-170 of human collagen IV.1 It increases the expression of the extracellular matrix (ECM) factors collagen I, hyaluronan synthase 1, and fibronectin in primary human dermal fibroblasts (HDFs).2 Tetrapeptide GEKG (1 and 10 ppm) induces the secretion of procollagen from HDFs. It also increases the viability of HDFs with a synergistic effect when used in combination with injectable platelet-rich fibrin (i-PRF).1 Formulations containing tetrapeptide GEKG have been used in cosmetics.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Paccola, A.G.L., Santos, T.M.C.D., Minelo, M.C., et al. Synergistic effects of injectable platelet-rich fibrin and bioactive peptides on dermal fibroblast viability and extracellular matrix gene expression: An in vitro study. Molecules 30(16), 3415 (2025).

    2. Farwick, M., Grether-Beck, S., Marini, A., et al. Bioactive tetrapeptide GEKG boosts extracellular matrix formation: In vitro and in vivo molecular and clinical proof. Exp. Dermatol. 20(7), 602-604 (2011).