A synthetic cooling compound
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WS-23

Item No. 45818

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,2,3-trimethyl-2-(1-methylethyl)-butanamide
CAS Number
51115-67-4
Synonyms
  • Methyl Diisopropyl Propionamide
Molecular Formula
C10H21NO
Formula Weight
171.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C(C(C)C)(C(C)C)C)NC
InChi Code
InChI=1S/C10H21NO/c1-7(2)10(5,8(3)4)9(12)11-6/h7-8H,1-6H3,(H,11,12)
InChi Key
RWAXQWRDVUOOGG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    10 g

    $23

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    25 g

    $59

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    50 g

    $113

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    100 g

    $200

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    Product Description

    WS-23 is a synthetic cooling compound.1 It reduces actin polymerization and stability and inhibits mobility of BEAS-2B bronchial epithelial cells at 1.5-4.5 mg/ml. Aerosol administration of WS-23 (343 mg/m3) does not induce changes in respiratory symptoms, body weight or behavior and does not increase mortality in rats within 28 days of administration.2 Formulations containing WS-23 have been used as cooling agents in cosmetics, skin creams and lotions, and electronic cigarette (e-cigarette) liquids.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wong, M., Martinez, T., Tran, M., et al. A synthetic coolant (WS-23) in disposable electronic cigarettes impairs cytoskeletal function in EpiAirway microtissues exposed at the air liquid interface. Sci. Rep. 13(1), 16906 (2023).

    2. Wu, Z.-H., Liu, Y.-S., Li, X.-D., et al. Acute and subacute inhalation toxicity assessment of WS-23 in Sprague-Dawley rats. J. Appl. Toxicol. 41(11), 1826-1838 (2021).