An antiproliferative compound

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Product Categories

Product Type

Biochemicals

Research Area

Cancer

SARS-CoV-2-IN-33

Name: SARS-CoV-2-IN-33
Brand: -

Item No. 45838

SARS-CoV-2-IN-33 (SARS-CoV-2 Inhibitor 33, Severe Acute Respiratory Syndrome Coronavirus 2-IN-33, Severe Acute Respiratory Syndrome Coronavirus 2 Inhibitor 33, CAS Number: 299919-79-2)

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)

Technical Information

Formal Name

4,4′-[(3,4,5-trimethoxyphenyl)methylene]bis[3-methyl-1-phenyl-1H-pyrazol-5-ol

CAS Number

299919-79-2

Synonyms

SARS-CoV-2 Inhibitor 33
Severe Acute Respiratory Syndrome Coronavirus 2-IN-33
Severe Acute Respiratory Syndrome Coronavirus 2 Inhibitor 33

Molecular Formula

C₃₀H₃₀N₄O₅

Formula Weight

526.6

Purity

≥98%

Formulation (Request formulation change)

A solid

Solubility(Learn about Variance in Solubility)

DMSO: Soluble: ≥10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml

SMILES

CC1=NN(C(O)=C1C(C2=C(O)N(N=C2C)C3=CC=CC=C3)C4=CC(OC)=C(OC)C(OC)=C4)C5=CC=CC=C5

InChi Code

InChI=1S/C30H30N4O5/c1-18-25(29(35)33(31-18)21-12-8-6-9-13-21)27(20-16-23(37-3)28(39-5)24(17-20)38-4)26-19(2)32-34(30(26)36)22-14-10-7-11-15-22/h6-17,27,35-36H,1-5H3

InChi Key

KUOWSCYCAAGCPB-UHFFFAOYSA-N

Shipping & Storage Information

Storage

-20°C

Shipping

Room temperature in continental US; may vary elsewhere

Certificates of Analysis & Batch Specific Data

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1 mg

$49

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5 mg

$159

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10 mg

$270

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Product Description

SARS-CoV-IN-33 is a pyrazolone derivative that has antiproliferative activity.¹ It inhibits the proliferation of MCF-7 and MDA-MB-231 breast, HeLa cervical, and PC3 prostate cancer cells (IC₅₀s = 5.45, 9.47, 22.86, and 28.44 µM, respectively) but not Ishikawa endometrial adenocarcinoma or HEK293 cells (IC₅₀s = >40 µM for both).

WARNING This product is not for human or veterinary use.

References & Product Citations

Product Description References

1. Gupta, A., Iqbal, S., Roohi, et al. Visible light-promoted green and sustainable approach for one pot synthesis of 4,4’-(arylmethylene)bis(1H-pyrazol-5-ols), in vitro anticancer activity, and molecular docking with Covid-19 Mpro. ACS Omega 7(38), 34583-34598 (2022).

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