A Gαi1 inhibitor
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0990CL

Item No. 45877

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(1,6-dihydro-4,6,6-trimethyl-2-pyrimidinyl)-4-phenyl-2-quinazolinamine
CAS Number
511514-03-7
Molecular Formula
C21H21N5
Formula Weight
343.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
CC1=CC(C)(NC(NC2=NC(C3=CC=CC=C3)=C4C(C=CC=C4)=N2)=N1)C
InChi Code
InChI=1S/C21H21N5/c1-14-13-21(2,3)26-20(22-14)25-19-23-17-12-8-7-11-16(17)18(24-19)15-9-5-4-6-10-15/h4-13H,1-3H3,(H2,22,23,24,25,26)
InChi Key
DXICUHJLOMNKOU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $225

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    5 mg

    $450

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    10 mg

    $675

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    Product Description

    0990CL is an inhibitor of the G protein subtype Gαi1.1 It inhibits Gαi1 nucleotide exchange by 25% and Gαq nucleotide exchange by <10% at 300 µM. 0990CL (0.1 µM) reverses UK 14304-induced decreases in cAMP in forskolin-stimulated HEK293 cells expressing the α2-adrenergic receptor (α2-AR).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Appleton, K.M., Bigham, K.J., Lindsey, C.C., et al. Development of inhibitors of heterotrimeric Gαi subunits. Bioorg. Med. Chem. 22(13), 3423-3434 (2015).