An NSAID and COX inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Indobufen

Item No. 45931

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-ethyl-benzeneacetic acid
CAS Number
63610-08-2
Synonyms
  • K 3920
Molecular Formula
C18H17NO3
Formula Weight
295.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
CCC(C(O)=O)C(C=C1)=CC=C1N2CC3=C(C2=O)C=CC=C3
InChi Code
InChI=1S/C18H17NO3/c1-2-15(18(21)22)12-7-9-14(10-8-12)19-11-13-5-3-4-6-16(13)17(19)20/h3-10,15H,2,11H2,1H3,(H,21,22)
InChi Key
AYDXAULLCROVIT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    250 mg

    $35

    Add

    500 mg

    $67

    Add

    1 g

    $91

    Add

    5 g

    $315

    Add
    Lipid Resource Center
    Discover Products & Resources for Lipid Research
    • High-purity lipid standards
    • Lipid roles in biology
    • Lipids in health & disease
    • Lipids for pharmaceutical development
    • Protocols, advice, & resources
    EXPLORE NOW
    Product Description

    Indobufen is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor.1 It reduces thromboxane B2 (TXB2) but not prostaglandin E2 (PGE2) levels in LPS-stimulated isolated human monocytes. Indobufen inhibits collagen-induced ATP release and platelet aggregation in isolated human platelet-rich plasma (PRP).2 It reduces arachidonic acid-induced mortality in mice and rabbits (ED50s = 1.3 and 0.58 mg/kg, respectively).3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eligini, S., Violi, F., Banfi, C., et al. Indobufen inhibits tissue factor in human monocytes through a thromboxane-mediated mechanism. Cardiovasc. Res. 69(1), 218-226 (2006).

    2. Cattaneo, M., Bevilacqua, C., Lecchi, A., et al. In vitro and ex vivo effects of indobufen on human platelet aggregation, the release reaction and thromboxane B2 production. Haemostasis 17(5), 293-300 (1987).

    3. Bergamaschi, M., Pierucci, L., and Branzoli, U. Inhibitory activity of indobufen (*) on platelet aggregation in vivo. Pharmacol. Res. Commun. 16(10), 979-985 (1984).