A chemotactic peptide and matrikine
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Chemotactic Domain of Elastin (trifluoroacetate salt)

Item No. 45933

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-valylglycyl-L-valyl-L-alanyl-L-prolylglycine, bis(trifluoroacetate)
CAS Number
3053365-59-3
Synonyms
  • Hexapeptide 12
  • Val-Gly-Val-Ala-Pro-Gly-OH
Molecular Formula
C22H38N6O7 • 2CF3COOH
Formula Weight
602.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
VGVAPG-OH
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (7.2 pH): Sparingly soluble: 1-10 mg/ml
SMILES
CC(C)[C@H](N)C(NCC(N[C@@H](C(C)C)C(N[C@@H](C)C(N1[C@@H](CCC1)C(NCC(O)=O)=O)=O)=O)=O)=O.FC(F)(F)C(O)=O.FC(F)(F)C(O)=O
InChi Code
InChI=1S/C22H38N6O7.2C2HF3O2/c1-11(2)17(23)20(33)24-9-15(29)27-18(12(3)4)21(34)26-13(5)22(35)28-8-6-7-14(28)19(32)25-10-16(30)31;2*3-2(4,5)1(6)7/h11-14,17-18H,6-10,23H2,1-5H3,(H,24,33)(H,25,32)(H,26,34)(H,27,29)(H,30,31);2*(H,6,7)/t13-,14-,17-,18-;;/m0../s1
InChi Key
NJWHGGHWBKVGIT-UHUBGAAPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Chemotactic domain of elastin is an elastin-derived peptide (EDP) and matrikine.1,2 It induces migration of primary bovine fibroblasts and isolated human monocytes at 10 nM.1 Chemotactic domain of elastin also induces migration of M-27 Lewis lung carcinoma cells in vitro (EC50 = ~3 nM).3 It increases the production of reactive oxygen species (ROS) in primary mouse astrocytes at 0.1 nM.4 Chemotactic domain of elastin (150 µg/kg) decreases lifespan, locomotor activity, and lean tissue percentage, increases body weight and fat tissue percentage, and induces kyphosis in mice.2 Conjugation of chemotactic domain of elastin to a cell-penetrating peptide (CPP) increases the transfection efficiency of nucleic acid complexes.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Senior, R.M., Griffin, G.L., Mecham, R.P., et al. Val-Gly-Val-Ala-Pro-Gly, a repeating peptide in elastin, is chemotactic for fibroblasts and monocytes. J. Cell Biol. 99(3), 870-874 (1984).

    2. Yi, J., Wang, Y., Sui, H., et al. Elastin-derived extracellular matrix fragments drive aging through innate immune activation. Nat. Aging 5(12), 2380-2398 (2025).

    3. Blood, C.H., Sasse, J., Brodt, P., et al. Identification of a tumor cell receptor for VGVAPG, an elastin-derived chemotactic peptide. J. Cell Biol. 107(5), 1987-1993 (1988).

    4. Szychowski, K.A., and Gmiński, J. The VGVAPG peptide regulates the production of nitric oxide synthases and reactive oxygen species in mouse astrocyte cells in vitro. Neurochem. Res. 44(5), 1127-1137 (2019).

    5. Shen, W.-J., Tian, D.-M., Fu, L., et al. Elastin-derived VGVAPG fragment decorated cell-penetrating peptide with improved gene delivery efficacy. Pharmaceutics 15(2), 670 (2023).