A 5-HT4 receptor agonist
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RS 67333 (hydrochloride)

Item No. 45937

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-1-propanone, monohydrochloride
CAS Number
168986-60-5
Molecular Formula
C19H29ClN2O2 • HCl
Formula Weight
389.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
O=C(CCC1CCN(CC1)CCCC)C2=C(OC)C=C(N)C(Cl)=C2.Cl
InChi Code
InChI=1S/C19H29ClN2O2.ClH/c1-3-4-9-22-10-7-14(8-11-22)5-6-18(23)15-12-16(20)17(21)13-19(15)24-2;/h12-14H,3-11,21H2,1-2H3;1H
InChi Key
XVBGLZNYWUUAFF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $89

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    10 mg

    $142

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    50 mg

    $534

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    100 mg

    $890

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    Product Description

    RS 67333 is an agonist of the serotonin (5-HT) receptor subtype 5-HT4.1 It selectively binds to 5-HT4 (Ki = 2 nM) over 5-HT1A, 5-HT2A, 5-HT2C, and 5-HT3 receptors (Kis = 398, 501, 794, and 398 nM, respectively), as well as α- and β-adrenergic and muscarinic receptors (Kis = >200 nM for all). It also binds to σ1- and σ2-receptors (Kis = 1 and 10 nM, respectively). RS 67333 induces relaxation of carbachol-precontracted rat esophageal muscularis mucosae preparations (EC50 = 2 nM) and induces tachycardia in anesthetized micropigs at 4.9 µg/kg. It reverses scopolamine-induced memory deficits in mice in the Y-maze test when administered at a dose of 1 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Eglen, R.M., Bonhaus, D.W., Johnson, L.G., et al. Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br. J. Pharmacol. 115(8), 1387-1392 (1995).

    2. Lelong, V., Lhonneur, L., Dauphin, F., et al. BIMU 1 and RS 67333, two 5-HT4 receptor agonists, modulate spontaneous alternation deficits induced by scopolamine in the mouse. Naunyn Schmiedebergs Arch Pharmacol. 367(6), 621-628 (2003).