A tubulin polymerization inhibitor and anticancer agent
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Auristatin PE

Item No. 45983

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N,N-dimethyl-L-valyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[(2-phenylethyl)amino] ropyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide
CAS Number
149606-27-9
Synonyms
  • NSC 654663
  • Soblidotin
  • TZT-1027
  • YHI-501
Molecular Formula
C39H67N5O6
Formula Weight
702.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetontrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(NCCC1=CC=CC=C1)[C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@@H](N(C)C)C(C)C)=O)=O)=O)OC
InChi Code
InChI=1S/C39H67N5O6/c1-13-27(6)35(43(10)39(48)33(25(2)3)41-38(47)34(26(4)5)42(8)9)31(49-11)24-32(45)44-23-17-20-30(44)36(50-12)28(7)37(46)40-22-21-29-18-15-14-16-19-29/h14-16,18-19,25-28,30-31,33-36H,13,17,20-24H2,1-12H3,(H,40,46)(H,41,47)/t27-,28+,30-,31+,33-,34-,35-,36+/m0/s1
InChi Key
DZMVCVHATYROOS-ZBFGKEHZSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $139

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    5 mg

    $348

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    10 mg

    $487

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    Cayman Chemical
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    Product Description

    Auristatin PE is a tubulin polymerization inhibitor, an anticancer agent, and a derivative of dolastatin 10.1 It inhibits tubulin polymerization (IC50< = 2.2 µM), completely inhibits the proliferation of WSU-WM Waldenström's macroglobulinemia cells at 100 pg/ml, and induces cell cycle arrest at the G2/M phase and apoptosis in the same cells at 10 pg/ml.1,2 Auristatin PE induces tumor regression in MX-1 breast cancer, LX-1 lung cancer, and WSU-WM mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kobayashi, M., Natsume, T., Tamaoki, S., et al. Antitumor activity of TZT-1027, a novel dolastatin 10 derivative. Jpn. J. Cancer Res. 88(3), 316-327 (1997).

    2. Mohammad, R.M., Limvarapuss, C., Wall, N.R., et al. A new tubulin ploymerization inhibitor, auristatin PE, induces tumor regression in a human Waldenstrom’s macroglobulinemia xenograft model. Int. J. Oncol. 15, 367-372 (1999).