A FOXP3 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Peptide P60

Item No. 45998

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-α-aspartyl-L-phenylalanyl-L-glutaminyl-L-seryl-L-phenylalanyl-L-arginyl-L-lysyl-L-methionyl-L-tryptophyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-methionine
CAS Number
1319725-20-6
Molecular Formula
C95H132N24O20S2
Formula Weight
1994.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Peptide Sequence
RDFQSFRKMWPFFAM-OH
SMILES
O=C(N(CCC1)[C@@H]1C(N[C@H](C(N[C@H](C(N[C@@H](C)C(N[C@H](C(O)=O)CCSC)=O)=O)CC2=CC=CC=C2)=O)CC3=CC=CC=C3)=O)[C@@H](NC([C@H](CCSC)NC([C@H](CCCCN)NC([C@H](CCCNC(N)=N)NC([C@@H](NC([C@H](CO)NC([C@H](CCC(N)=O)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](N)CCCNC(N)=N)=O)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=CC=C5)=O)=O)=O)=O)CC6=CNC7=CC=CC=C67
InChi Code
InChI=1S/C95H132N24O20S2/c1-55(79(124)111-68(93(138)139)40-46-141-3)106-85(130)69(47-56-23-8-4-9-24-56)113-88(133)72(50-59-29-14-7-15-30-59)116-91(136)76-36-22-44-119(76)92(137)74(51-60-53-105-63-33-17-16-31-61(60)63)117-84(129)67(39-45-140-2)110-81(126)64(34-18-19-41-96)107-82(127)65(35-21-43-104-95(101)102)108-86(131)71(49-58-27-12-6-13-28-58)115-90(135)75(54-120)118-83(128)66(37-38-77(98)121)109-87(132)70(48-57-25-10-5-11-26-57)114-89(134)73(52-78(122)123)112-80(125)62(97)32-20-42-103-94(99)100/h4-17,23-31,33,53,55,62,64-76,105,120H,18-22,32,34-52,54,96-97H2,1-3H3,(H2,98,121)(H,106,130)(H,107,127)(H,108,131)(H,109,132)(H,110,126)(H,111,124)(H,112,125)(H,113,133)(H,114,134)(H,115,135)(H,116,136)(H,117,129)(H,118,128)(H,122,123)(H,138,139)(H4,99,100,103)(H4,101,102,104)/t55-,62-,64-,65-,66-,67-,68-,69-,70-,71-,72-,73-,74-,75-,76-/m0/s1
InChi Key
CYTCHHWJGBKDPS-UZFQJSGKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $75

    Add

    5 mg

    $300

    Add

    10 mg

    $488

    Add

    25 mg

    $844

    Add
    Cayman Chemical
    Visit Our Cancer Resource Center
    Find Tools & Resources to Study the Hallmarks of Cancer
    • Cancer cell signaling & regulation
    • Cancer metabolism
    • Tumor microenvironment
    EXPLORE NOW
    Product Description

    Peptide P60 is an inhibitor of forkhead box protein P3 (FOXP3).1 It binds to recombinant human FOXP3 at 5 µM and inhibits the nuclear translocation of FOXP3-GFP in HEK293 cells at 10 µM. Peptide P60 reverses FOXP3-induced inhibition of basal NF-κB activity in HEK293T cells and PMA- and ionomycin-induced NFAT activity in Jurkat cells in reporter assays. It increases effector T cell proliferation in a mixed lymphocyte reaction at 100 µM. Peptide P60 (50 nmol/animal, i.p.) improves the immunogenicity and antitumor activity of an AH1 peptide vaccine in a CT26 murine colorectal cancer model, and it increases the efficacy of an RAdNS3 vaccine in a mouse model of hepatitis C virus (HCV) infection at the same dose.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Casares, N., Rudilla, F., Arribillaga, L., et al. A peptide inhibitor of FOXP3 impairs regulatory T cell activity and improves vaccine efficacy in mice. J. Immunol. 185(9), 5150-5159 (2010).