A lung-targeted ionizable cationic lipid
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Lipid 392

Item No. 46050

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N',N'''-(12-(2-hydroxydecyl)-8-methyl-15,18-dioxo-4-(3-oxopropyl)-4,8,12,16,17-pentaazatritriacontanoyl)di(palmitohydrazide)
CAS Number
3047517-72-3
Molecular Formula
C74H147N9O7
Formula Weight
1275.0
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/ml
SMILES
CN(CCCN(CC(O)CCCCCCCC)CCC(NNC(CCCCCCCCCCCCCCC)=O)=O)CCCN(CCC(NNC(CCCCCCCCCCCCCCC)=O)=O)CCC(NNC(CCCCCCCCCCCCCCC)=O)=O
InChi Code
InChI=1S/C74H147N9O7/c1-6-10-14-18-22-25-28-31-34-37-40-44-48-54-69(85)75-78-72(88)57-64-82(65-58-73(89)79-76-70(86)55-49-45-41-38-35-32-29-26-23-19-15-11-7-2)62-51-60-81(5)61-52-63-83(67-68(84)53-47-43-21-17-13-9-4)66-59-74(90)80-77-71(87)56-50-46-42-39-36-33-30-27-24-20-16-12-8-3/h68,84H,6-67H2,1-5H3,(H,75,85)(H,76,86)(H,77,87)(H,78,88)(H,79,89)(H,80,90)
InChi Key
GQYLYFAKALCNNW-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $110

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    10 mg

    $209

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    25 mg

    $358

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    Cayman Chemical
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    Product Description

    Lipid 392 is a lung-targeted ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA, single-guide (sgRNA), or siRNA in vivo.1 Simplified targeted LNPs (stLNPs) containing lipid 392 and encapsulating Cre recombinase mRNA are delivered to the lung, resulting in gene editing efficiencies of approximately 68, 70, and 32% for lung endothelial, epithelial, and immune cells, respectively, in Ai14 reporter mice. Lipid 392-containing stLNPs encapsulating IL-10 mRNA reduce lung inflammation and damage in a mouse model of acute lung injury.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Fei, Y., Lin, Y., Liu, P., et al. Optimization of lipid nanoparticles for safe and versatile lung-targeted RNA delivery and disease therapy. ACS Nano 20(21), 15347-15362 (2026).