A near-infrared indocyanine dye
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IR 820

Item No. 46066

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-[2-chloro-3-[2-[1,3-dihydro-1,1-dimethyl3-(4-sulfobutyl)-2H-benz[e]indol-2-ylidene]ethylidene]-1-cyclohexen-1-yl]ethenyl]-1,1-dimethyl-3-(4-sulfobutyl)-1H-benz[e]indolium, inner salt, monosodium salt
CAS Number
172616-80-7
Molecular Formula
C46H50ClN2O6S2 • Na
Formula Weight
849.5
Emission
820 nm
Excitation
710 nm
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
λmax
218, 266, 406 nm
SMILES
CC1(C(C2=CC=CC=C2C=C3)=C3[N+](CCCC[S](=O)([O-])=O)=C1C=CC(CCCC4=CC=C(C5(C)C)N(C6=C5C7=CC=CC=C7C=C6)CCCC[S](=O)([O-])=O)=C4Cl)C.[Na+]
InChi Code
InChI=1S/C46H51ClN2O6S2.Na/c1-45(2)40(48(28-9-11-30-56(50,51)52)38-24-20-32-14-5-7-18-36(32)42(38)45)26-22-34-16-13-17-35(44(34)47)23-27-41-46(3,4)43-37-19-8-6-15-33(37)21-25-39(43)49(41)29-10-12-31-57(53,54)55;/h5-8,14-15,18-27H,9-13,16-17,28-31H2,1-4H3,(H-,50,51,52,53,54,55);/q;+1/p-1
InChi Key
RANIQVAJHXBIAY-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    100 mg

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    Product Description

    IR 820 is a near-infrared (NIR) indocyanine dye.1 It displays excitation/emission maxima of 710/820 nm, respectively. IR 820 has been used as a blood pool contrast agent in mice for in vivo NIR fluorescence imaging of diseased tissue, including tumors and stroke-affected tissues, and to monitor the time course of muscle injury over multiple days. It has also been used in the synthesis of tumor-targeted fluorescent probes.2 In addition, IR 820 has been encapsulated in liposomes as a photothermal therapy component in combination with protoporphyrin IX (PpIX) as a photosensitizer to form nanoparticles that synergistically reduce the viability of HeLa cells when used with irradiation.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Prajapati, S.I., Martinez, C.O., Bahadur, A.N., et al. Near-infrared imaging of injured tissue in living subjects using IR-820. Mol. Imaging 8(1), 45-54 (2009).

    2. Yuan, X., Zhang, Y., Xuan, J., et al. αvβ3 integrin-targeted IR-820 dye-based small molecule probe for fluorescence imaging of tumor. J. Photochem. Photobiol. B 278, 113437 (2026).

    3. Yan, T., Alimu, G., Zhu, L., et al. PpIX/IR-820 dual-modal therapeutic agents for enhanced PDT/PTT synergistic therapy in cervical cancer. ACS Omega 7(49), 44643-44656 (2022).