A derivative of L-asparagine
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H-Asn(GlcNAc-β-D)-OH

Item No. 46070

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[2-(acetylamino)-2-deoxy-β-D-glucopyranosyl]-L-asparagine
CAS Number
2776-93-4
Synonyms
  • AADG
  • 2-Acetamido-1-(β-L-aspartamido)-1,2-dideoxyglucose
  • N-Acetylglucosaminylasparagine
  • Aspartylglycosamine
Molecular Formula
C12H21N3O8
Formula Weight
335.3
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C(N[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O)O)NC(C)=O)C[C@@H](C(O)=O)N
InChi Code
InChI=1S/C12H21N3O8/c1-4(17)14-8-10(20)9(19)6(3-16)23-11(8)15-7(18)2-5(13)12(21)22/h5-6,8-11,16,19-20H,2-3,13H2,1H3,(H,14,17)(H,15,18)(H,21,22)/t5-,6+,8+,9+,10+,11+/m0/s1
InChi Key
YTTRPBWEMMPYSW-HRRFRDKFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $25

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    5 mg

    $106

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    10 mg

    $188

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    25 mg

    $375

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    Product Description

    H-Asn(GlcNAc-β-D)-OH is a derivative of the amino acid L-asparagine (Asn; Item Nos. 35022 | 34519). During the catabolism of Asn-linked glycoproteins in the lysosome, H-Asn(GlcNAc-β-D)-OH is hydrolyzed via aspartylglucosaminidase to form Asn and N-acetylglucosamine (GlcNAc).1,2 Urinary levels of H-Asn(GlcNAc-β-D)-OH are increased in patients with aspartylglycosaminuria, a lysosomal storage disorder characterized by neurological deficits and skeletal abnormalities.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Aronson, N.N.J., and Kuranda, M.J. Lysosomal degradation of Asn-linked glycoproteins. The FASEB Journal 3(14), 2615-2622 (1989).

    2. Mononen, I., Fisher, K.J., Kaartinen, V., et al. Aspartylglycosaminuria: Protein chemistry and molecular biology of the most common lysosomal storage disorder of glycoprotein degradation. The FASEB Journal 7(13), 1247-1256 (1993).