A limonoid with diverse biological activities
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Rutaevin

Item No. 46079

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(4aS,6aS,8R,8aS,8bR,9aS,12S,12aS,14aR,14bR)-12-(3-furanyl)octahydro-8-hydroxy-6,6,8a,12a-tetramethyl-1H,3H,6H,8H-oxireno[c]pyrano[4′′,3′′:2′,3′]furo[3′,4′:5,6]naphtho[1,2-d]pyran-3,7,10(6aH,9aH)-trione
CAS Number
33237-37-5
Molecular Formula
C26H30O9
Formula Weight
486.5
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
C[C@]([C@@]1([H])[C@]([C@@](C2)([H])OC(C)3C)(COC2=O)[C@]3([H])C4=O)([C@H]4O)[C@@]5([C@]6([H])O5)[C@]([C@H](C7=COC=C7)OC6=O)(CC1)C
InChi Code
InChI=1S/C26H30O9/c1-22(2)17-16(28)18(29)24(4)13(25(17)11-32-15(27)9-14(25)34-22)5-7-23(3)19(12-6-8-31-10-12)33-21(30)20-26(23,24)35-20/h6,8,10,13-14,17-20,29H,5,7,9,11H2,1-4H3/t13-,14-,17+,18-,19-,20+,23-,24-,25-,26+/m0/s1
InChi Key
YZMKFMIZNSOPSN-ZIQVUAKTSA-N
Origin
Plant/Cortex Dictamni
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $179

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    10 mg

    $269

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    25 mg

    $582

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    50 mg

    $985

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    Product Description

    Rutaevin is a limonoid that has been found in L. olgensis and has diverse biological activities.1,2,3 It acts as a phytoalexin in L. olgensis, where it accumulates in the shoots of trees resistant to larch shoot blight following exposure to the plant pathogenic fungus N. laricinum.1 It also reduces LPS-induced increases in nitric oxide (NO) production in RAW 264.7 macrophages (IC50 = 151.6 µM) and reduces glutamate-induced neurotoxicity in primary rat cortical cells (EC50 = 3.1 µM).2,3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, R., Zhang, S., Xia, R., et al. From resistance mechanism to green application: Discovery of rutaevin as a key phytoalexin in larch and cross-species resource optimization. Plants (Basel) 14(19), 2947 (2025).

    2. Yang, X.B., Qian, P., Yang, X.W., et al. Limonoid constituents of Euodia rutaecarpa var. bodinieri and their inhibition on NO production in lipopolysaccharide-activated RAW264.7 macrophages. J. Asian Nat. Prod. Res. 15(10), 1130-1138 (2013).

    3. Yoon, J.S., Sung, S.H., and Kim, Y.C. Neuroprotective limonoids of root bark of Dictamnus dasycarpus. J. Nat. Prod. 7(2), 208-211 (2008).