Acetylcorynoline

Acetylcorynoline is an alkaloid that has been found in C. bungeana and has diverse biological activities.^1,2,3 It reduces the half-life of c-Myc, inhibits proliferation, induces apoptosis, and induces cell cycle arrest at the G₂/M phase in HCT116 colon carcinoma cells expressing or not expressing p53.¹ Acetylcorynoline (10 and 20 µM) reduces the secretion of TNF-α, IL-6, and IL-12 p70 by mouse bone marrow-derived dendritic cells (BMDCs) stimulated with LPS. It also reduces delayed-type hypersensitivity in mice sensitized with 2,4-dinitro-1-fluorobenzene (DNFB) when administered at a dose of 100 µg/animal.² It has anti-parkinsonism effects in Parkinson’s disease models using various strains of C. elegans, including reducing dopaminergic cell degeneration, preventing α-synuclein aggregation, and increasing dopamine levels and lifespan.³

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1. Park, Y.-R., Jee, W., Park, S.-M., et al. Acetylcorynoline induces apoptosis and G₂/M phase arrest through the c-Myc signaling pathway in colon cancer cells. Int. J. Mol. Sci. 24(24), 17589 (2023).

2. Fu, R.-H., Wang, Y.-C., Liu, S.-P., et al. Acetylcorynoline impairs the maturation of mouse bone marrow-derived dendritic cells via suppression of IκB kinase and mitogen-activated protein kinase activities. PLoS One 8(3), e58398 (2013).

3. Fu, R.-H., Wang, Y.-C., Chen, C.-S., et al. Acetylcorynoline attenuates dopaminergic neuron degeneration and α-synuclein aggregation in animal models of Parkinson’s disease. Neuropharmacology 82, 108-120 (2014).