A flavonoid glycoside with diverse biological activities
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Puerarin 6''-O-xyloside

Item No. 46083

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-hydroxy-3-(4-hydroxyphenyl)-8-(6-O-β-D-xylopyranosyl-β-D-glucopyranosyl)-4H-1-benzopyran-4-one
CAS Number
114240-18-5
Synonyms
  • P6OX
  • POS
  • PRX
  • PXY
Molecular Formula
C26H28O13
Formula Weight
548.5
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O[C@H]1[C@H](C2=C3OC=C(C(C3=CC=C2O)=O)C4=CC=C(O)C=C4)O[C@H](CO[C@@H]5OC[C@H]([C@@H]([C@H]5O)O)O)[C@@H](O)[C@@H]1O
InChi Code
InChI=1S/C26H28O13/c27-11-3-1-10(2-4-11)13-7-36-24-12(18(13)30)5-6-14(28)17(24)25-22(34)21(33)20(32)16(39-25)9-38-26-23(35)19(31)15(29)8-37-26/h1-7,15-16,19-23,25-29,31-35H,8-9H2/t15-,16-,19+,20-,21+,22-,23-,25+,26+/m1/s1
InChi Key
YCFQXQCEEPCZMO-KATYHMCLSA-N
Origin
Plant/Pueraria lobata
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $45

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    5 mg

    $180

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    10 mg

    $248

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    25 mg

    $506

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    Product Description

    Puerarin 6’’-O-xyloside is a flavonoid glycoside that has been found in P. lobata and has diverse biological activities.1,2,3 It induces apoptosis in A549 lung cancer cells and reduces tumor volume in an A549 mouse xenograft model when administered at a dose of 40 mg/kg.1 Puerarin 6’’-O-xyloside decreases PPARα and carnitine palmitoyltransferase 1A (CPT1A) levels in HepG2 cells stimulated by oleic acid (Item Nos. 90260 | 24659) and palmitic acid (Item Nos. 10006627 | 43561).2 It reduces serum triglyceride, total cholesterol, and LDL-C levels, fasting blood glucose levels, lipid droplet accumulation, and body weight in a model of menopause using ovariectomized mice fed a high-fat diet (HFD). Puerarin 6’’-O-xyloside induces proliferation of isolated rat osteocytes, increases serum calcium, phosphorus, alkaline phosphatase (ALP), and osteoprotegerin levels, and increases thickening of the trabecular bone in a model of osteoporosis using ovariectomized mice.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, T., Chen, H., Wang, Y., et al. In vitro and in vivo antitumour activities of puerarin 6″-O-xyloside on human lung carcinoma A549 cell line via the induction of the mitochondria-mediated apoptosis pathway. Pharm. Biol. 54(9), 1793-1799 (2016).

    2. Wang, D., You, Y., Luo, T., et al. Puerarin 6″-O-xyloside improves postmenopausal lipid metabolic disorders via the PPARα-mediated FAO pathway. Phytomedicine 152:157833, (2026).

    3. Li, H., Chen, B., Pang, G., et al. Anti-osteoporotic activity of puerarin 6"-O-xyloside on ovariectomized mice and its potential mechanism. Pharm. Biol. 54(1), 111-117 (2016).