A potential impurity in commercial preparations of formoterol
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Formoterol EP Impurity A

Item No. 46098

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-amino-4-hydroxy-α-[[[2-(4-methoxyphenyl)-1-methylethyl]amino]methyl]-benzenemethanol
CAS Number
150513-24-9
Synonyms
  • FMTR-RS-1
  • Formoterol deformylated
Molecular Formula
C18H24N2O3
Formula Weight
316.4
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
COC1=CC=C(CC(NCC(C2=CC=C(O)C(N)=C2)O)C)C=C1
InChi Code
InChI=1S/C18H24N2O3/c1-12(9-13-3-6-15(23-2)7-4-13)20-11-18(22)14-5-8-17(21)16(19)10-14/h3-8,10,12,18,20-22H,9,11,19H2,1-2H3
InChi Key
AMISPUNGCBUARA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Formoterol EP impurity A is a potential impurity in commercial preparations of the β2-adrenergic receptor (β2-AR) agonist formoterol.1 It is a degradation product formed by acid or base hydrolysis or thermal, photolytic, or hydrolytic stress.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Simhachalam, P., Sabithakala, T., Satyanarayana, K.V.V., et al. A novel stability-indicating method development and validation using reverse-phase ultra–high-performance liquid chromatography (RP- UPLC-PDA) technique for quantification of related substances and assay of formoterol fumarate in its inhalation solution (20 μg mL−2). Acta Chromatagr. 38(1), 164-179 (2026).