An anticancer agent
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Product Categories

Product Type

Biochemicals

Research Area

Cancer
Cell Signaling
Growth Factor Receptor Signaling

EX-A16580

Item No. 46100

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1-[(3-endo)-3-[[4-[[2-fluoro-3-methyl-4-([1,2,4]-triazolo[1,5-a]pyridin-7-yloxy)phenyl]amino]-6-quinazolinyl]oxy]-8-azabicyclo[3.2.1]oct-8-yl]-2-propen-1-one
CAS Number
2989904-86-9
Molecular Formula
C31H28FN7O3
Formula Weight
565.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
C=CC(N1[C@@]2([H])C[C@@H](C[C@]1([H])CC2)OC3=CC4=C(C=C3)N=CN=C4NC5=C(C(C)=C(C=C5)OC6=CC7=NC=NN7C=C6)F)=O
InChi Code
InChI=1S/C31H28FN7O3/c1-3-29(40)39-19-4-5-20(39)13-23(12-19)41-21-6-7-25-24(14-21)31(35-16-33-25)37-26-8-9-27(18(2)30(26)32)42-22-10-11-38-28(15-22)34-17-36-38/h3,6-11,14-17,19-20,23H,1,4-5,12-13H2,2H3,(H,33,35,37)/t19-,20+,23+
InChi Key
WEOIUNUHGPJUAV-NPHXMPSESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    10 mg

    $207

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    Cayman Chemical
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    Product Description

    EX-A16580 is an anticancer agent.1 It selectively inhibits the proliferation of Ba/F3 cells expressing wild-type HER2 or the exon 20 insertion mutant HER2 A775_G776 insYVMA over those expressing wild-type EGFR (GI50s = 4.1, 3.4, and 3,742 nM, respectively).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, X., Wang, B., Dong, H., et al. Nitrogen-containing heterocyclic compound, preparation method therefor, and pharmaceutical application thereof. (2025).