An S100P inhibitor
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S100P-IN-1

Item No. 46108

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(1,3,3a,4,9,9a-hexahydro-4-nitro-1,3-dioxo-4,9[1′,2′]-benzeno-2H-benz[f]isoindol-2-yl)-benzoic acid
CAS Number
690991-06-1
Synonyms
  • S100 Calcium-binding Protein P Inhibitor 1
  • S100 Calcium-binding Protein P-IN-1
  • S100P Inhibitor 1
Molecular Formula
C25H16N2O6
Formula Weight
440.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Sparingly soluble: 1-10 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(C1=CC=CC(N2C(C3C4C5=C(C(C3C2=O)([N+]([O-])=O)C6=C4C=CC=C6)C=CC=C5)=O)=C1)O
InChi Code
InChI=1S/C25H16N2O6/c28-22-20-19-15-8-1-3-10-17(15)25(27(32)33,18-11-4-2-9-16(18)19)21(20)23(29)26(22)14-7-5-6-13(12-14)24(30)31/h1-12,19-21H,(H,30,31)
InChi Key
MJGGCGYBUPPFMU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    S100P-IN-1 is an inhibitor of S100 calcium-binding protein P (S100P).1 It inhibits the binding of S100P to its receptor, the receptor for advanced glycation end products (RAGE; IC50 = 22.7 nM). S100P-IN-1 (10 µM) selectively inhibits the invasion of BxPC-3 pancreatic cancer cells, which endogenously express S100P, over PANC-1 pancreatic cancer cells, which do not express S100P. It reduces tumor size and inhibits M2 polarization of tumor-associated macrophages in a subcutaneous murine Lewis lung carcinoma model at 10 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Camara, R., Ogbeni, D., Gerstmann, L., et al. Discovery of novel small molecule inhibitors of S100P with in vitro anti-metastatic effects on pancreatic cancer cells. Eur. J. Med. Chem. 203, 112621 (2020).

    2. Gao, L., Bai, Y., Zhou, J., et al. S100P facilitates LUAD progression via PKA/c-Jun-mediated tumor-associated macrophage recruitment and polarization. Cell Signal. 120, 111179 (2024).