An ionizable cationic lipid
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AO12

Item No. 46148

Product Insert (PDF)
Technical Information
Formal Name
heptadecan-9-yl 8-((2-((3-(4-hydroxyphenyl)propanoyl)oxy)ethyl)(6-oxo-6-(undecyloxy)hexyl)amino)octanoate
Molecular Formula
C53H95NO7
Formula Weight
858.3
Purity
≥98%
Formulation (Request formulation change)
A solution in 10 mg/ml methyl acetate
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly soluble: 1-10 mg/mlMethyl Acetate: Soluble: ≥10 mg/mL
SMILES
O=C(CCCCCCCN(CCCCCC(OCCCCCCCCCCC)=O)CCOC(CCC1=CC=C(O)C=C1)=O)OC(CCCCCCCC)CCCCCCCC
InChi Code
InChI=1S/C53H95NO7/c1-4-7-10-13-16-17-18-24-32-46-59-51(56)35-29-25-31-44-54(45-47-60-52(57)42-39-48-37-40-49(55)41-38-48)43-30-23-19-22-28-36-53(58)61-50(33-26-20-14-11-8-5-2)34-27-21-15-12-9-6-3/h37-38,40-41,50,55H,4-36,39,42-47H2,1-3H3
InChi Key
PWHKRIGJAYNLMF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $39

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    5 mg

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    10 mg

    $234

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    Cayman Chemical
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    Product Description

    AO12 is an ionizable cationic lipid that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of mRNA, circular RNA (circRNA), and single-guide RNA (sgRNA) in vitro and in vivo.1 It is a phenol-containing derivative of SM-102 (Item No. 33474) that reduces oxidative degradation of cargo mRNA and circRNA. LNPs containing AO12 accumulate in the liver. LNPs formulated with AO12 and encapsulating hepatocyte growth factor (HGF) mRNA reduce serum levels of alanine transaminase (ALT) and aspartate aminotransferase (AST) and decrease hepatic necrosis in a mouse model of acute liver injury induced by acetaminophen (Item No. 10024) or chronic liver fibrosis induced by carbon tetrachloride (CCl4). LNPs containing AO12 and encapsulating Cas9 mRNA and Nlrp3-targeting sgRNA reduce skin lesions, epidermal thickening, and skin tissue levels of IL-1β, IL-6, and TNF-α in a mouse model of psoriasis induced by imiquimod (IMQ; Item No. 14956).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, B., Zhao, M., Yang, B., et al. Antioxidant lipid nanoparticles enhance mRNA stability for regeneration therapy and gene editing. Nat. Commun. 17(1), 7166 (2026).