Bemotrizinol

Bemotrizinol is an oil-soluble, broad-spectrum UVA and UVB absorber.¹ An oil-in-water formulation of bemotrizinol only superficially penetrates the stratum corneum of excised porcine skin, indicating a low potential for transdermal permeation.² Topical administration of bemotrizinol (50 and 200 mg/g) reduces the development of skin tumors induced by UV radiation (UVR) in a model of simulated UVR exposure using hairless mice.³ It also has antioxidant activity as an acceptor of atomic oxygen (O(³P)).⁴ Bemotrizinol does not bind to estrogen or androgen receptors in cell-free assays and is inactive in an immature rat uterotrophic assay.⁵ Formulations containing bemotrizinol have been used as UV absorbers in sunscreens.

WARNING This product is not for human or veterinary use.

1. Herzog, B., Hüglin, D., Borsos, E., et al. New UV absorbers for cosmetic sunscreens – A breakthrough for the photoprotection of human skin. CHIMIA 58, 554 (2004).

2. Haque, T., Crowther, J.M., Lane, M.E., et al. Chemical ultraviolet absorbers topically applied in a skin barrier mimetic formulation remain in the outer stratum corneum of porcine skin. Int. J. Pharm. 510(1), 250-254 (2016).

3.  Twelve-month topical study to determine the influence of Tinosorb S (fat 70'884) on photocarcinogenesis in hairless mice. (2005).

4. Durán-Giner, N., Encinas, S., and Miranda, M.A. Solar filters as feasible acceptors of atomic oxygen. Photochem. Photobiol. Sci. 12(5), 725-728 (2013).

5. Ashby, J., Tinwell, H., Plautz, J., et al. Lack of binding to isolated estrogen or androgen receptors, and inactivity in the immature rat uterotrophic assay, of the ultraviolet sunscreen filters Tinosorb M-active and Tinosorb S. Regul. Toxicol. Pharmacol. 34(3), 287-291 (2001).