A phenolic glycoside with diverse biological activities
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Curculigoside

Item No. 46178

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[[(2,6-dimethoxybenzoyl)oxy]methyl]-4-hydroxyphenyl β-D-glucopyranoside
CAS Number
85643-19-2
Molecular Formula
C22H26O11
Formula Weight
466.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/ml
SMILES
O=C(C1=C(C=CC=C1OC)OC)OCC2=C(O[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CO)O)O)O)C=CC(O)=C2
InChi Code
InChI=1S/C22H26O11/c1-29-14-4-3-5-15(30-2)17(14)21(28)31-10-11-8-12(24)6-7-13(11)32-22-20(27)19(26)18(25)16(9-23)33-22/h3-8,16,18-20,22-27H,9-10H2,1-2H3/t16-,18-,19+,20-,22-/m1/s1
InChi Key
SJJRKHVKAXVFJQ-QKYBYQKWSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Product Description

    Curculigoside is a phenolic glycoside that has been found in C. orchioides and has diverse biological activities.1,2,3,4,5 It scavenges hydroxyl radicals and superoxide anions in cell-free assays (IC50s = 0.54 and 1.35 mM, respectively).1 Curculigoside protects against NMDA-induced excitotoxicity in primary mouse cortical neurons and decreases learning and memory deficits in aged rats.2,3 It decreases disease severity and inhibits colonic ferroptosis in a mouse model of ulcerative colitis at 100 mg/kg.4 Curculigoside reduces matrix metalloproteinase-9 (MMP-9), inducible nitric oxide synthase (iNOS), NF-κB, and NOD-like receptor protein 3 (NLRP3) levels in a mouse model of osteoarthritis.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wu, Q., Fu, D.-X., Hou, A.-J., et al. Antioxidative phenols and phenolic glycosides from Curculigo orchioides. Chem. Pharm. Bull. (Tokyo) 53(8), 1065-1067 (2005).

    2. Tian, Z., Yu, W., Liu, H.B., et al. Neuroprotective effects of curculigoside against NMDA-induced neuronal excitoxicity in vitro. Food. Chem. Toxicol. 50(11), 4010-4015 (2012).

    3. Wu, X.Y., Li, J.Z., Guo, J.Z., et al. Ameliorative effects of curculigoside from Curculigo orchioides Gaertn on learning and memory in aged rats. Molecules 17(9), 10108-10118 (2012).

    4. Wang, S., Liu, W., Wang, J., et al. Curculigoside inhibits ferroptosis in ulcerative colitis through the induction of GPX4. Life Sci. 259, 118356 (2020).

    5. Wang, X., Liu, Y., Zhou, Y., et al. Curculigoside inhibits osteoarthritis via the regulation of NLRP3 pathway. Eur. J. Histochem. 67(4), 3896 (2023).