An isoxazoline ectoparasiticide
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Lotilaner

Item No. 46179

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(5S)-4,5-dihydro-5-(3,4,5-trichlorophenyl)-5-(trifluoromethyl)-3-isoxazolyl]-3-methyl-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-2-thiophenecarboxamide
CAS Number
1369852-71-0
Molecular Formula
C20H14Cl3F6N3O3S
Formula Weight
596.8
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
ClC(C=C1[C@]2(C(F)(F)F)CC(C3=CC(C)=C(S3)C(NCC(NCC(F)(F)F)=O)=O)=NO2)=C(C(Cl)=C1)Cl
InChi Code
InChI=1S/C20H14Cl3F6N3O3S/c1-8-2-13(36-16(8)17(34)30-6-14(33)31-7-19(24,25)26)12-5-18(35-32-12,20(27,28)29)9-3-10(21)15(23)11(22)4-9/h2-4H,5-7H2,1H3,(H,30,34)(H,31,33)/t18-/m0/s1
InChi Key
HDKWFBCPLKNOCK-SFHVURJKSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Lotilaner is an isoxazoline ectoparasiticide.1,2 It is an antagonist of insect GABA-gated chloride channels (IC50 = 23.84 nM for the D. melanogaster channel) and is selective for insect channels over dog α1β2γ2 GABAA receptors at 10,000 nM.1 Lotilaner (20 mg/kg, p.o.) completely eliminates D. variabilis, R. sanguineus, A. americanum, and I. scapularis tick infestations in dogs after 48 hours.2 Formulations containing lotilaner have been used in the treatment of Demodex blepharitis and as veterinary anti-ectoparasitics.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Rufener, L., Danelli, V., Bertrand, D., et al. The novel isoxazoline ectoparasiticide lotilaner (Credelio™): A non-competitive antagonist specific to invertebrates γ-aminobutyric acid-gated chloride channels (GABACls). Parasit. Vectors 10(1), 530 (2017).

    2. Murphy, M., Garcia, R., Karadzovska, D., et al. Laboratory evaluations of the immediate and sustained efficacy of lotilaner (Credelio™) against four common species of ticks affecting dogs in North America. Parasit. Vectors 10(1), 523 (2017).