An SNRI and voltage-gated sodium channel inhibitor
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Enantiomer(s)
14317(S)-Duloxetine (hydrochloride)
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(R)-Duloxetine (hydrochloride)

Item No. 46209

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-methyl-γR-(1-naphthalenyloxy)-2-thiophenepropanamine, monohydrochloride
CAS Number
910138-96-4
Synonyms
  • LY248686
Molecular Formula
C18H19NOS • HCl
Formula Weight
333.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
CNCC[C@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl
InChi Code
InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m1./s1
InChi Key
BFFSMCNJSOPUAY-UNTBIKODSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $68

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    10 mg

    $109

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    25 mg

    $187

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    50 mg

    $306

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    Product Description

    (R)-Duloxetine is a serotonin and norepinephrine reuptake inhibitor (SNRI) and voltage-gated sodium channel inhibitor.1,2 It selectively inhibits neurotransmitter reuptake in HEK cells expressing the serotonin transporter (SERT) or norepinephrine transporter (NET; IC50s = 2.6 and 13.2 nM, respectively) over cells expressing the dopamine transporter (DAT; IC50 = 809 nM).1 It also selectively inhibits inactivated over resting voltage-gated sodium channels in GH3 rat pituitary cells (IC50s = 5.82 and 33.8 µM, respectively).2 Subcutaneous administration of (R)-duloxetine (2 mg) reduces allodynia and hyperalgesia in a rat model of postoperative pain induced by skin incision plus extension (SIE).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cashman, J.R., and Ghirmai, S. Inhibition of serotonin and norepinephrine reuptake and inhibition of phosphodiesterase by multi-target inhibitors as potential agents for depression. Bioorg. Med. Chem. 17(19), 6890-6897 (2009).

    2. Wang, C.-F., Russell, G., Wang, S.-Y., et al. R-Duloxetine and N-methyl duloxetine as novel analgesics against experimental postincisional pain. Anesth. Analg. 122(3), 719-729 (2016).