An internal standard for the quantification of hippuric acid
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Hippuric Acid-d5

Item No. 46213

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-(benzoyl-2,3,4,5,6-d5)-glycine
CAS Number
53518-98-2
Molecular Formula
C9H4D5NO3
Formula Weight
184.2
Purity
≥99% deuterated forms (d1-d5)
Formulation (Request formulation change)
A solid
SMILES
[2H]C1=C(C(NCC(O)=O)=O)C([2H])=C(C([2H])=C1[2H])[2H]
InChi Code
InChI=1S/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)/i1D,2D,3D,4D,5D
InChi Key
QIAFMBKCNZACKA-RALIUCGRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $32

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    5 mg

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    10 mg

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    Product Description

    Hippuric acid-d5 is intended for use as an internal standard for the quantification of hippuric acid by GC- or LC-MS. Hippuric acid is a glycine conjugate of benzoic acid.1 It is formed in vivo from benzoic acid by CoA and glycine via a benzoyl-CoA intermediate in the human liver and renal cortex and is excreted in the urine. Hippuric acid reduces the levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and increases the levels of reactive oxygen species (ROS) and fibrosis-related proteins, including collagen I and α-smooth muscle actin (α-SMA), in HK-2 kidney epithelial cells.2 It reduces renal Nrf2 levels and induces renal fibrosis and redox imbalance in a rat model of chronic kidney disease at 100 mg/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Lees, H.J., Swann, J.R., Wilson, I.D., et al. Hippurate: The natural history of a mammalian-microbial cometabolite. J. Proteome Res. 12(4), 1527-1546 (2013).

    2. Sun, B., Wang, X., Liu, X., et al. Hippuric acid promotes renal fibrosis by disrupting redox homeostasis via facilitation of NRF2-KEAP1-CUL3 interactions in chronic kidney disease. Antioxidants (Basel) 9(9), 783 (2020).