An antiviral agent
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Leritrelvir

Item No. 46231

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(1S,3aR,6aS)-2-[(2S)-2-cyclohexyl-2-[(2,2,2-trifluoroacetyl)amino]acetyl]-N-[(1S)-3-(cyclopentylamino)-2,3-dioxo1-[[(3S)-2-oxo-3-pyrrolidinyl]methyl]propyl]octahydro-cyclopenta[c]pyrrole-1-carboxamide
CAS Number
2923310-64-7
Synonyms
  • Leruiling
  • RAY1216
Molecular Formula
C31H44F3N5O6
Formula Weight
639.7
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C([C@H]([C@](CCC1)([H])[C@]1([H])C2)N2C([C@H](C3CCCCC3)NC(C(F)(F)F)=O)=O)N[C@H](C(C(NC4CCCC4)=O)=O)C[C@H](CCN5)C5=O
InChi Code
InChI=1S/C31H44F3N5O6/c32-31(33,34)30(45)38-23(17-7-2-1-3-8-17)29(44)39-16-19-9-6-12-21(19)24(39)27(42)37-22(15-18-13-14-35-26(18)41)25(40)28(43)36-20-10-4-5-11-20/h17-24H,1-16H2,(H,35,41)(H,36,43)(H,37,42)(H,38,45)/t18-,19-,21-,22-,23-,24-/m0/s1
InChi Key
ICGMMLTUQDVAST-HEZDJTGRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Leritrelvir is an antiviral agent.1,2 It inhibits the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease (Mpro) that is also known as the 3C-like protease (3CLpro; Ki = 8.4 nM).1 It reduces viral titers of seven SARS-CoV-2 variants (EC50s = 69-135 nM plaque assays) and decreases lung viral titers, lung tissue inflammation injury, and lethality in a K18-hACE2 mouse model of SARS-CoV-2 infection. Leritrelvir inhibits replication of coxsackievirus B4 (CVB4) in HeLa cells (EC50 = 12.64 nM) and reduces viral replication, virus-induced organ lesions, and lethality in CVB4-infected mice at 12 mg/kg.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Chen, X., Huang, X., Ma, Q., et al. Preclinical evaluation of the SARS-CoV-2 Mpro inhibitor RAY1216 shows improved pharmacokinetics compared with nirmatrelvir. Nat. Microbiol. 9(4), 1075-1088 (2024).

    2. Liu, Q., Tang, B., Xuan, X., et al. The potential of leritrelvir repositioning for the treatment of coxsackievirus B4 and common enterovirus infections. Antiviral Res. 248, 106367 (2026).