An anti-tuberculosis agent
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Mtb ATP Synthase-IN-1

Item No. 46247

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
3-(1,3-benzodioxol-5-ylamino)-4-[(2-pyridinylmethyl)amino]-3-cyclobutene-1,2-dione
CAS Number
2642394-38-3
Synonyms
  • Mtb ATP Synthase Inhibitor 1
Molecular Formula
C17H13N3O4
Formula Weight
323.3
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
O=C1C(NCC2=CC=CC=N2)=C(C1=O)NC3=CC=C4OCOC4=C3
InChi Code
InChI=1S/C17H13N3O4/c21-16-14(19-8-11-3-1-2-6-18-11)15(17(16)22)20-10-4-5-12-13(7-10)24-9-23-12/h1-7,19-20H,8-9H2
InChi Key
ZEYYGLIHJGBVNS-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $35

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    5 mg

    $105

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    10 mg

    $175

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    25 mg

    $350

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    Cayman Chemical
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    Product Description

    Mtb ATP synthase-IN-1 is an anti-tuberculosis agent.1 It is active against a drug-sensitive and two extensively drug-resistant (XDR) M. tuberculosis strains (MICs = 0.483, 0.47, and 0.499 µg/ml, respectively) and does not induce cytotoxicity in Vero cells (IC50 = >64 µg/ml).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, P., Wang, B., Li, G., et al. Design, synthesis and biological evaluation of diamino substituted cyclobut-3-ene-1,2-dione derivatives for the treatment of drug-resistant tuberculosis. Eur. J. Med. Chem. 206, 112538 (2020).