An aminoglycoside antibiotic
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Isepamicin (sulfate)

Item No. 46262

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
O-6-amino-6-deoxy-α-D-glucopyranosyl-(1→4)-O-[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)]-N1-[(2S)-3-amino-2-hydroxy-1-oxopropyl]-2-deoxy-D-streptamine, sulfate
CAS Number
67814-76-0
Synonyms
  • Sch 21420 (sulfate)
Molecular Formula
C22H43N5O12 • XH2SO4
Formula Weight
569.6
Purity
≥95%
Formulation (Request formulation change)
A solid
SMILES
O=C(N[C@H](C[C@@H]([C@H]([C@@H]1O)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)O)N)[C@@H]1O[C@@H]3[C@@H]([C@H]([C@@](O)(CO3)C)NC)O)[C@H](CN)O.OS(O)(=O)=O
InChi Code
InChI=1S/C22H43N5O12.H2O4S/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21;1-5(2,3)4/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34);(H2,1,2,3,4)/t7-,8+,9-,10+,11+,12-,13+,14-,15+,16+,17-,18+,20+,21+,22-;/m0./s1
InChi Key
DDXRHRXGIWOVDQ-MGAUJLSLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

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    Cayman Chemical
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    Product Description

    Isepamicin is an aminoglycoside antibiotic.1 It is active against 419 clinical isolates of Enterobacteriaceae species, including E. coli, K. pneumoniae, and S. marcescens (MICs = 0.25-<128 mg/L for all).2 Isepamicin (7 mg/kg) has bactericidal activity in a neutropenic mouse model of S. aureus infection with a post-antibiotic effect (PAE) lasting approximately five hours.1

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Minguez Minguez, F., Izquierdo Izquierdo, J., Caminero, M.M., et al. In vivo postantibiotic effect of isepamicin and other aminoglycosides in a thigh infection model in neutropenic mice. Chemotherapy 38(3), 179-184 (1992).

    2. Cheng, N.-C., Hsueh, P.-R., Liu, Y.-C., et al. In vitro activities of tigecycline, ertapenem, isepamicin, and other antimicrobial agents against clinically isolated organisms in Taiwan. Microb. Drug Resist. 11(4), 330-341 (2005).