A cyclic metastasis-homing peptide
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BLMP6 (trifluoroacetate salt)

Item No. 46267

Technical Information
Formal Name
(4R,10S,16S,22S,25S,28R)-28-amino-10,25-bis(3-guanidinopropyl)-16-isopropyl-22-methyl-6,9,12,15,18,21,24,27-octaoxo-1,2-dithia-5,8,11,14,17,20,23,26-octaazacyclononacosane-4-carboxylic acid, trifluoroacetate salt
Synonyms
  • Breast Lung Metastasis-homing Peptide 6
  • cyclo(Cys-Arg-Ala-Gly-Val-Gly-Arg-Gly-Cys)-OH
Molecular Formula
C32H57N15O10S2 • XCF3COOH
Formula Weight
Purity
≥95%
A solid
Peptide Sequence
[CRAGVGRGC]-OH
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/mlPBS, pH 7.2: Soluble: ≥10 mg/ml
SMILES
O=C([C@@H](N)CSSC[C@@H](C(O)=O)N1)N[C@H](C(N[C@@H](C)C(NCC(N[C@H](C(NCC(N[C@H](C(NCC1=O)=O)CCCNC(N)=N)=O)=O)C(C)C)=O)=O)=O)CCCNC(N)=N.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C32H57N15O10S2.C2HF3O2/c1-15(2)24-29(55)42-11-21(48)44-18(6-4-8-38-31(34)35)27(53)41-10-22(49)45-20(30(56)57)14-59-58-13-17(33)26(52)46-19(7-5-9-39-32(36)37)28(54)43-16(3)25(51)40-12-23(50)47-24;3-2(4,5)1(6)7/h15-20,24H,4-14,33H2,1-3H3,(H,40,51)(H,41,53)(H,42,55)(H,43,54)(H,44,48)(H,45,49)(H,46,52)(H,47,50)(H,56,57)(H4,34,35,38)(H4,36,37,39);(H,6,7)/t16-,17-,18-,19-,20-,24-;/m0./s1
InChi Key
CRKGBKPTWJKEJN-XPXZCRDWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    BLMP6 is a cyclic metastasis-homing peptide.1 It mimics the EGF-like calcium-binding domain 6 of latent TGF-β-binding protein 4 (LTBP4) and selectively binds to fibulin-4 (FIBL-4) over FIBL-3 (Kds = 0.318 and 635 µM, respectively). Fluorescently labeled BLMP6 selectively labels metastatic breast cancer biopsies over adjacent control breast tissue and non-ductal breast cancer biopsies in human tissue arrays.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Daquinag, A.C., Ghosh, S.C., AghaAmiri, S., et al. Fibulin-4 expressed in metastatic breast cancer is a target of peptide-based imaging probes and experimental therapeutics. Mol. Ther. Oncol. 34(2), 201207 (2026).