A chromone with diverse biological activities
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Cimifugin

Item No. 46280

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2S)-2,3-dihydro-7-(hydroxymethyl)-2-(1-hydroxy-1-methylethyl)-4-methoxy-5H-furo[3,2-g][1]benzopyran-5-one
CAS Number
37921-38-3
Synonyms
  • Cimitin
Molecular Formula
C16H18O6
Formula Weight
306.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
O=C1C2=C(C=C3O[C@@H](CC3=C2OC)C(C)(C)O)OC(CO)=C1
InChi Code
InChI=1S/C16H18O6/c1-16(2,19)13-5-9-11(22-13)6-12-14(15(9)20-3)10(18)4-8(7-17)21-12/h4,6,13,17,19H,5,7H2,1-3H3/t13-/m0/s1
InChi Key
ATDBDSBKYKMRGZ-ZDUSSCGKSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $44

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    10 mg

    $66

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    25 mg

    $110

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    50 mg

    $154

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    Product Description

    Cimifugin is a chromone that has been found in S. divaricata and has diverse biological activities.1,2,3,4 It reduces palmitate-induced cell death in AML12 hepatocytes at 10-40 µM and reduces reactive oxygen species (ROS) levels and toll-like receptor 4 (TLR4) expression in the same cells at 40 µM.2 It also reduces oleate-induced lipid accumulation in AML12 and HepG2 cells. Cimifugin (6.25 and 12.5 mg/kg) prevents relapse in a mouse model of house dust mite-induced asthma relapse, where it reduces the number of eosinophils in peripheral blood and the levels of IL-5 in bronchoalveolar lavage fluid (BALF).3 It inhibits calcium influx induced by the transient receptor potential vanilloid 4 (TRPV4) agonist GSK1016790A (Item No. 17289) in HaCaT keratinocytes at 9.75 µM.4 Topical administration of cimifugin (1.625-8.125 mM) reduces GSK1016790A-induced scratching behavior in a mouse model of psoriasis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Patel, D.K. Biological importance of bioactive phytochemical ‘Cimifugin’ as potential active pharmaceutical ingredients against human disorders: A natural phytochemical for new therapeutic alternatives. Pharmacol. Res. Mod. Chin. Med. 7, 100232 (2023).

    2. Yang, W., Zhu, L., Lai, S., et al. Cimifugin ameliorates lipotoxicity-induced hepatocyte damage and steatosis through TLR4/p38 MAPK- and SIRT1-involved pathways. Oxid. Med. Cell. Longev. 2022, 4557532 (2022).

    3. Gu, A., Zheng, J., Wang, X., et al. Cimifugin relieves the relapse of allergic asthma via inhibiting ILC2 migration by targeting CCR9. J. Ethnopharmacol. 363, 121429 (2026).

    4. Yan, J., Ye, F., Ju, Y., et al. Cimifugin relieves pruritus in psoriasis by inhibiting TRPV4. Cell Calcium 97, 102429 (2021).