A negative allosteric modulator of FSHR
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ADX-68692

Item No. 46306

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[4-(1-cyano-1-methylethyl)-3-(3-pyridinyl)phenyl]-3,4-dimethoxy-benzamide
CAS Number
1067191-08-5
Molecular Formula
C24H23N3O3
Formula Weight
401.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
N#CC(C)(C)C1=CC=C(NC(C2=CC=C(C(OC)=C2)OC)=O)C=C1C3=CN=CC=C3
InChi Code
InChI=1S/C24H23N3O3/c1-24(2,15-25)20-9-8-18(13-19(20)17-6-5-11-26-14-17)27-23(28)16-7-10-21(29-3)22(12-16)30-4/h5-14H,1-4H3,(H,27,28)
InChi Key
AMOZYIARVZBSIH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $25

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    5 mg

    $113

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    10 mg

    $200

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    25 mg

    $438

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    Product Description

    ADX-68692 is a negative allosteric modulator of the follicle-stimulating hormone receptor (FSHR) that reduces FSH-stimulated increases in progesterone and estradiol levels in primary rat granulosa cells (IC50s = 1 and 0.82 µM, respectively).1 It inhibits estrus and FSH-stimulated ovulation in female rats.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Dias, J.A., Campo, B., Weaver, B.A., et al. Inhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor. Biol. Reprod. 90(1), 19 (2014).