An antioxidant and a mitochondrial dynamics regulator
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MC1

Item No. 46326

Product Insert (PDF)
Technical Information
Formal Name
3-(3,4-dihydroxyphenyl)-N-(2-(5-methoxy-1H-indol-3-yl)ethyl)propanamide
Molecular Formula
C20H22N2O4
Formula Weight
354.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Soluble: ≥10 mg/ml
SMILES
OC1=CC(CCC(NCCC2=CNC3=C2C=C(C=C3)OC)=O)=CC=C1O
InChi Code
InChI=1S/C20H22N2O4/c1-26-15-4-5-17-16(11-15)14(12-22-17)8-9-21-20(25)7-3-13-2-6-18(23)19(24)10-13/h2,4-6,10-12,22-24H,3,7-9H2,1H3,(H,21,25)
InChi Key
KLTVZIHYWIPLGO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $54

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    5 mg

    $203

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    10 mg

    $378

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    Product Description

    MC1 is an antioxidant, a mitochondrial dynamics regulator, and a conjugate of melatonin (Item No. 14427) and catechol (Item No. 34791).1 It selectively scavenges peroxyl over hydroxyl radicals (IC50s = 0.0376 and 16.3 µM, respectively) and inhibits ferroptosis induced by erastin (Item No. 17754) or RSL3 (Item No. 19288) in PC12 cells; however, although it decreases total cellular reactive oxygen species (ROS), it also increases mitochondrial superoxide and hydrogen peroxide levels. MC1 elongates mitochondria, indicating mitochondrial fusion, reverses doxorubicin-induced decreases in mitochondrial membrane potential, and increases ATP production in PC12 cells. It decreases lipofuscin levels and lipid deposits, markers of aging, and increases lifespan in C. elegans at 50 µM.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qian, C., Zhang, Y., Dang, X., et al. A melatonin-catechol hybrid molecule prolongs lifespan via regulating ROS and reprogramming mitochondrial metabolism. J. Med. Chem. (2026).