A gadolinium-based contrast agent
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Gadodiamide

Item No. 46334

Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
[5,8-bis[(carboxy-κO)methyl]-11-[2-(methylamino)-κN8,κN11,κO13]-(oxo-κO)ethyl]-3-(oxo-κO)-2,5,8,11-tetraazatridecan-13-oato(3-)-κN5-2-gadolinium
CAS Number
131410-48-5
Synonyms
  • Gd-DTPA-BMA
Molecular Formula
C16H26GdN5O8
Formula Weight
573.7
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
CNC1=[O][Gd+3]2([N](C3)(C4)CC5)([O]=C3NC)([O-]C6=O)([O-]C4=O)([O-]C7=O)[N]5(C7)CC[N]2(C6)C1
InChi Code
InChI=1S/C16H29N5O8.Gd/c1-17-12(22)7-20(10-15(26)27)5-3-19(9-14(24)25)4-6-21(11-16(28)29)8-13(23)18-2;/h3-11H2,1-2H3,(H,17,22)(H,18,23)(H,24,25)(H,26,27)(H,28,29);/q;+3/p-3
InChi Key
HZHFFEYYPYZMNU-UHFFFAOYSA-K
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    250 mg

    $149

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    500 mg

    $283

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    1 g

    $536

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    5 g

    $1,788

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    Product Description

    Gadodiamide is a gadolinium-based contrast agent (GBCA).1,2,3 It induces apoptosis and autophagy in HaCaT keratinocytes and SVG p12 glial cells at 13 mM.1,2 Gadodiamide (2.5 mmol/kg) induces nephrogenic systemic fibrosis-like skin lesions in rats.3 Formulations containing gadodiamide have been used as contrast agents for diagnostic MRI.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tsai, Y.F., Yang, J.S., Chiu, Y.J., et al. Gadodiamide induced autophagy and apoptosis in human keratinocytes. In Vivo 36(2), 603-609 (2022).

    2. Tsai, Y.F., Yang, J.S., Tsai, F.J., et al. In vitro toxicological assessment of gadodiamide in normal brain SVG P12 cells. In Vivo 35(5), 2621-2630 (2021).

    3. Sieber, M.A., Pietsch, H., Walter, J., et al. A preclinical study to investigate the development of nephrogenic systemic fibrosis: A possible role for gadolinium-based contrast media. Invest. Radiol. 43(1), 65-75 (2008).