A flavone glycoside that has diverse biological activities
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Pectolinarin

Item No. 46336

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one
CAS Number
28978-02-1
Molecular Formula
C29H34O15
Formula Weight
622.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O[C@H]([C@@H]([C@H]([C@@H](O1)C)O)O)[C@@H]1OC[C@@H](O[C@H]2OC(C=C3OC(C4=CC=C(OC)C=C4)=CC(C3=C5O)=O)=C5OC)[C@@H](O)[C@H](O)[C@H]2O
InChi Code
InChI=1S/C29H34O15/c1-11-20(31)23(34)25(36)28(41-11)40-10-18-21(32)24(35)26(37)29(44-18)43-17-9-16-19(22(33)27(17)39-3)14(30)8-15(42-16)12-4-6-13(38-2)7-5-12/h4-9,11,18,20-21,23-26,28-29,31-37H,10H2,1-3H3/t11-,18+,20-,21+,23+,24-,25+,26+,28+,29+/m0/s1
InChi Key
DUXQKCCELUKXOE-CBBZIXHGSA-N
Origin
Plant/Cirsium japonicum
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $45

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    10 mg

    $77

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    25 mg

    $180

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    50 mg

    $248

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    Cayman Chemical
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    Product Description

    Pectolinarin is a flavone glycoside originally isolated from L. vulgaris that has diverse biological activities.1,2,3,4,5,6 It inhibits hydrogen peroxide-induced reactive oxygen species (ROS) accumulation and apoptosis in SK-N-SH cells.2 Pectolinarin (10-20 mg/kg, p.o.) reduces hepatic damage and lipid peroxidation and increases the activity of hepatic superoxide dismutase (SOD) in a rat model of liver injury induced by D-galactosamine (Item No. 22981).3 It reduces ear edema induced by arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) in mice and inhibits the passive cutaneous anaphylaxis (PCA) reaction in rats.4 Pectolinarin reduces proliferation in a variety of cancer cells (IC50s = 5.03-14.12 µM) but not MRC-5 fibroblasts (IC50s = >80 µM).5 It also increases complement hemolytic activity in an H22 hepatoma mouse allograft model and increases lymphocyte proliferation and spleen and thymus weights while reducing tumor weight in H22 and Sarcoma 180 mouse allograft models at 50 mg/kg.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Cheriet, T., Ben-Bachir, B., Thamri, O., et al. Isolation and biological properties of the natural flavonoids pectolinarin and pectolinarigenin-A review. Antibiotics (Basel) 9(7), 417 (2020).

    2. Chung, M.J., Lee, S., Park, Y.I., et al. Neuroprotective effects of phytosterols and flavonoids from Cirsium setidens and Aster scaber in human brain neuroblastoma SK-N-SH cells. Life Sci. 148, 173-182 (2016).

    3. Yoo, Y.-M., Nam, J.-H., Kim, M.-Y., et al. Pectolinarin and pectolinarigenin of Cirsium setidens prevent the hepatic injury in rats caused by D-Galactosamine via an antioxidant mechanism. Biol. Pharm. Bull. 31(4), 760-764 (2008).

    4. Lim, H., Son, K.H., Chang, H.W., et al. Anti-inflammatory activity of pectolinarigenin and pectolinarin isolated from Cirsium chanroenicum. Biol. Pharm. Bull. 31(11), 2063-2067 (2008).

    5. Tundis, R., Deguin, B., Loizzo, M.R., et al. Potential antitumor agents: Flavones and their derivatives from Linaria reflexa Desf. Bioorg. Med. Chem. Lett. 15(21), 4757-4760 (2005).

    6. Liu, S., Luo, X., Li, D., et al. Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. Int. Immunopharmacol. 6(9), (2006).