An antitumor tripeptide
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Tyroserleutide (trifluoroacetate salt)

Item No. 46338

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tyrosyl-L-seryl-L-leucine, trifluoroacetate salt
Molecular Formula
C18H27N3O6 • XCF3COOH
Formula Weight
381.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
YSL-OH
Solubility(Learn about Variance in Solubility)
Ethanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
CC(C)C[C@@H](C(O)=O)NC([C@@H](NC([C@H](CC1=CC=C(O)C=C1)N)=O)CO)=O.O=C(O)C(F)(F)F
InChi Code
InChI=1S/C18H27N3O6.C2HF3O2/c1-10(2)7-14(18(26)27)20-17(25)15(9-22)21-16(24)13(19)8-11-3-5-12(23)6-4-11;3-2(4,5)1(6)7/h3-6,10,13-15,22-23H,7-9,19H2,1-2H3,(H,20,25)(H,21,24)(H,26,27);(H,6,7)/t13-,14-,15-;/m0./s1
InChi Key
YUBDOPZMLWMWCV-WDTSGDEMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $66

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    5 mg

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    10 mg

    $495

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    25 mg

    $990

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    Cayman Chemical
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    Product Description

    Tyroserleutide is an antitumor tripeptide.1,2,3 It inhibits the invasion of MHCC97-L hepatocellular carcinoma (HCC) cells at 100 µg/ml.2 Tyroserleutide induces the production of IL-1β, TNF-α, and nitric oxide (NO) in isolated mouse peritoneal macrophages and enhances the cytotoxic effect of isolated mouse peritoneal macrophages against BEL-7402 HCC and B16/F10 melanoma cells.3 It increases survival in an H22 murine hepatoma model at 10-80 µg/kg and decreases the rate of pulmonary metastasis in an MHCC97-L mouse xenograft model at 160 µg/kg.1,2 Tyroserleutide also decreases radiation-induced increases in intratumoral levels of transmembrane serine protease 4 (TMPRSS4) and hypoxia-inducible factor 1α (HIF-1α) in an MHCC97-L mouse xenograft model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, C., Ding, W., Zhao, M., et al. Studies on the large scale synthesis and anti-tumor activity of YSL. Prep. Biochem. Biotechnol. 33(3), 189-195 (2003).

    2. Jia, J.-B., Wang, W.-Q., Sun, H.-C., et al. A novel tripeptide, tyroserleutide, inhibits irradiation-induced invasiveness and metastasis of hepatocellular carcinoma in nude mice. Invest. New Drugs 29(5), 861-872 (2011).

    3. Yao, Z., Qiu, S., Wang, L., et al. Tripeptide tyroserleutide enhances the antitumor effects of macrophages and stimulates macrophage secretion of IL-1β, TNF-α, and NO in vitro. Cancer Immunol. Immunother. 55(1), 56-60 (2006).