BSA antibody-based immune complexes for the induction of innate immune responses
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Product Categories

Product Type

Antibodies

Research Area

Immunology & Inflammation
Innate Immunity

Immune Complexes (Precipitating, BSA-Antibody)

Item No. 46363

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Bovine Serum Albumin-Antibody Complex
  • IC Reagent
  • Rabbit Anti-BSA BSA Complex
Formulation (Request formulation change)
1 mg of immune complexes in PBS
Storage Buffer
PBS, pH 7.2
Host
Rabbit
Applications
Addition to cell culture media for stimulation of primary human leukocytes
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    1 mg

    $799

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    Cayman Chemical
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    Product Description

    Immune Complexes (Precipitating, BSA-Antibody) are composed of BSA coated with an anti-BSA rabbit polyclonal antibody at a saturating concentration. Similar BSA-anti-BSA antibody immune complexes have been used to stimulate respiratory burst in M1-polarized bone marrow-derived macrophages (BMDMs) and peritoneal macrophages (pMACs) and to induce reactive oxygen species (ROS) production in BMDMs through Fcγ receptor (FcγR) cross-linking.1,2 Cayman’s Immune Complexes (Precipitating, BSA-Antibody) can be used for cell culture applications to elicit innate immune responses.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zajd, C.M., Ziemba, A.M., Miralles, G.M., et al. Bone marrow derived and elicited peritoneal macrophages are not created equal: The questions asked dictate the cell type used. Front. Immunol. 11, 269 (2020).

    2. Franchini, A.M., Hunt, D., Melendez, J.A., et al. FcγR-driven release of IL-6 by macrophages requires NOX2-dependent production of reactive oxygen species. The Journal of Biological Chemisty 288(35), 25098-25108 (2013).