A TRPM3 inhibitor
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BHV-2100

Item No. 46380

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
N-[(1S)-2-amino-1-(hydroxymethyl)-2-oxoethyl]-2-methyl-5-[(2-methyl-5-thiazolyl)methoxy]-3-benzofurancarboxamide
CAS Number
2776175-74-5
Synonyms
  • Ponometrep
Molecular Formula
C18H19N3O5S
Formula Weight
389.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
NC([C@@H](NC(C1=C(OC2=CC=C(OCC3=CN=C(S3)C)C=C21)C)=O)CO)=O
InChi Code
InChI=1S/C18H19N3O5S/c1-9-16(18(24)21-14(7-22)17(19)23)13-5-11(3-4-15(13)26-9)25-8-12-6-20-10(2)27-12/h3-6,14,22H,7-8H2,1-2H3,(H2,19,23)(H,21,24)/t14-/m0/s1
InChi Key
DWSIRZILHAGBKQ-AWEZNQCLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $45

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    5 mg

    $191

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    10 mg

    $315

    Add
    Product Description

    BHV-2100 is an inhibitor of transient receptor potential melastatin 3 (TRPM3; IC50s = 1-10 nM for the human, mouse, and rat receptors).1 It reduces pain induced by intraplantar injection of pregnenolone sulfate (Item No. 21004) in mice and rats (ED50s = 1.3 and 2.5 mg/kg, respectively) without inducing lethargy and with no effects on core body temperature or heart rate.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Vriens, J., Vanherck, J.-C., Marchand, A., et al. BHV-2100, a first-in-class TRPM3 antagonist for the treatment of pain (S13.002). Neurology 102(7_Supp_1), 6059 (2014).